Antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory

controlpeptidecomprimary

A high-affinity antibody in opposition to the CSP N-terminal area lacks Plasmodium falciparum inhibitory exercise

 

Malaria is a worldwide well being concern, and analysis efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To information immunogen design, we search a complete understanding of the protecting humoral response in opposition to Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP).
In distinction to the well-studied responses to the repeat area and the C-terminus, the antibody response in opposition to the N-terminal area of PfCSP (N-CSP) stays obscure. Right here, we characterised the molecular recognition and useful efficacy of the N-CSP-specific monoclonal antibody 5D5.
The crystal construction at 1.85-Å decision revealed that 5D5 binds an α-helical epitope in N-CSP with excessive affinity via in depth form and cost complementarity and the bizarre utilization of an antibody N-linked glycan. Nonetheless, useful research indicated low 5D5 binding to reside Pf sporozoites and lack of sporozoite inhibition in vitro and in vivo. Total, our knowledge don’t assist the inclusion of the 5D5 N-CSP epitope into the following era of CSP-based vaccines.

Conjugation Website Influences Antibody-Conjugated Drug PK Assays: Case Research for Disulfide-Linked, Self-Immolating SubsequentTechnology Antibody Drug Conjugates

 

Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are broadly used within the area for antibody drug conjugates (ADCs) containing peptide linkers which can be enzymatically cleavable, similar to MC-ValCit-PAB. Conjugate PK assay methods for these ADCs contain cleavage with cathepsin B or papain to launch and measure the antibody-conjugated drug (acDrug) focus.
Nonetheless, sturdy acDrug PK strategies for disulfide-linked self-immolating ADCs are missing as they’re a distinct conjugation modality. We developed acDrug PK assays for next-generation disulfide-linked ADCs involving immunoaffinity seize, chemical cleavage, and LC-MS/MS.
Disulfide-linked ADCs captured from plasma had been chemically lowered at primary pH to launch the linker-drug, adopted by self-immolation to liberate the energetic drug, and quantified by MRM LC-MS/MS. Herein, we element the event and optimization of this chemical cleavage acDrug PK assay, leading to sturdy accuracy and precision (<u>+</u>20%).
The conjugation website of the linker-drug on the antibody was discovered to have an effect on the kinetics of drug launch. A number of biophysical and chemical traits, similar to tertiary construction, fractional solvent accessibility, pKa of the conjugation website, surrounding residue’s pI, and electrostatic cost, could immediately impression the drug launch kinetics. Comparable site-specific stability has been beforehand reported for ADCs in vivo.
The assay growth and qualification knowledge for this unique assay format are offered together with its utility to a number of in vitro and in vivo research throughout species.
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controlpeptidecomprimary

Activin B

PR15012 5 ug
EUR 451.2

Activin B

cyt-058 2µg
EUR 60
Description: Recombinant Human Activin-B

Human Activin B,ACV-B ELISA Kit

YLA4164HU-48T 48T
EUR 435

Human Activin B,ACV-B ELISA Kit

YLA4164HU-96T 96T
EUR 562.5

Recombinant Human Activin-B Active

7-00010 1ug Ask for price

Recombinant Human Activin-B Active

7-00011 5ug Ask for price

Recombinant Human Activin-B Active

7-00012 100µg Ask for price

Human Activin B, ACV-B GENLISA ELISA

KBH6519 1 x 96 wells
EUR 286

Recombinant Human Activin-B, Plant

7-00013 2µg Ask for price

Recombinant Human Activin-B, Plant

7-00014 10µg Ask for price

Recombinant Human Activin-B, Plant

7-00015 1mg Ask for price

Recombinant Human Activin B Protein

PROTP09529-2 5ug
EUR 380.4
Description: Activin B is a TGF-β family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues. *Manufactured using BTI-Tn-5B1-4 cells under license from the Boyce Thompson Institute for Plant Research, Inc

Human Activin B (ACVB) CLIA Kit

abx196419-96tests 96 tests
EUR 990

Human Activin B (ACVB) CLIA Kit

20-abx491177
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Activin B ELISA Kit (ACVB)

RK00806 96 Tests
EUR 625.2

Human Activin B (ACVB) ELISA Kit

SEA170Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit

SEA170Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit

SEA170Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit

SEA170Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit

4-SEA170Hu
  • EUR 5188.80
  • EUR 2739.60
  • EUR 703.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Activin B (ACVB) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Activin B (ACVB) ELISA Kit

EKN43227-48T 48T
EUR 341.04

Human Activin B (ACVB) ELISA Kit

EKN43227-5x96T 5x96T
EUR 2314.2

Human Activin B (ACVB) ELISA Kit

EKN43227-96T 96T
EUR 487.2

Human Activin B (ACVB) ELISA Kit

SL2844Hu 96 Tests
EUR 468

Human Activin B (ACVB) ELISA Kit

EKU02116-48T 48T
EUR 500.5

Human Activin B (ACVB) ELISA Kit

EKU02116-5x96T 5x96T
EUR 3396.25

Human Activin B (ACVB) ELISA Kit

EKU02116-96T 96T
EUR 715

Human Activin B (INHBB) ELISA Kit

abx251961-96tests 96 tests
EUR 848.4

Human Activin B (INHBB) ELISA Kit

20-abx150537
  • EUR 7970.40
  • EUR 4250.40
  • EUR 990.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Activin-B Human Recombinant Protein

PROTP09529-1 Regular: 10ug
EUR 380.4
Description: Activin B human Recombinant produced in Nicotiana benthamiana plant is a beta-B single chain (aa 293-406) containing 123 amino acids (molecular formula C615H910N178O177S12). Activin B is fused to a 10-His-tag at the N-terminal having the total molecular mass of 14kDa and purified by standard chromatographic techniques.

Human ACVB(Activin B) ELISA Kit

EH2585 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human ACVB (Activin B) ELISA Kit

EKE60912-5x96T 5x96T
EUR 3124.08

Human ACVB (Activin B) ELISA Kit

EKE60912-96T 96T
EUR 657.7

Human ACVB(Activin B) ELISA Kit

ELK2858-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ACVB. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ACVB. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ACVB, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ACVB in the samples is then determined by comparing the OD of the samples to the standard curve.

Human ACVB(Activin B) ELISA Kit

ELK2858-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human ACVB. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human ACVB. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human ACVB, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human ACVB in the samples is then determined by comparing the OD of the samples to the standard curve.

Activin B, Active

cyt-057 2µg
EUR 60
Description: Recombinant Human Activin-B Active

Activin B, CF

PR15012CF 5 ug
EUR 451.2

Activin B,Mouse

E34M064M 5 μg
EUR 155

Activin-B Human Recombinant Protein, Active

PROTP09529 Regular: 10ug
EUR 380.4
Description: Activin B human Recombinant produced in Nicotiana benthamiana plant is a beta-B single chain (aa 293-406) containing 123 amino acids (molecular formula C615H910N178O177S12). Activin B is fused to a 10-His-tag at the N-terminal having the total molecular mass of 14kDa and purified by standard chromatographic techniques.

Anti-INHBB / Activin B Reference Antibody (Oxford Brookes U. anti-Activin Beta-B)

E24CHB014 100 μg
EUR 225
Description: Available in various conjugation types.

Activin-B Protein

20-abx262336
  • EUR 393.60
  • EUR 7609.20
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

CLIA kit for Human ACVB (Activin B)

E-CL-H0977 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human ACVB (Activin B) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human ACVB (Activin B)

E-EL-H1518 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human ACVB (Activin B) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human ACVB (Activin B)

ELK2858 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Activin B from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Human Activin B Recombinant Protein Lyophilized

IHUATVBRLY2UG each
EUR 317
Description: Human Activin B Recombinant Protein Lyophilized

Human Activin B Chemiluminescent Immunoassay Kit

IHUACVBKTC each
EUR 545
Description: Human Activin B Chemiluminescent Immunoassay Kit

Activin-A Activin A Human Recombinant Protein

PROTP08476-4 Regular: 10ug
EUR 380.4
Description: Activin-A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 137 amino acids (311-426) and having a molecular mass of 15.2kDa.;Activin-A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Activin-B Active Protein

20-abx263007
  • EUR 393.60
  • EUR 8427.60
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Activin-A Activin A Human Recombinant Protein, Plant

PROTP08476 Regular: 10ug
EUR 380.4
Description: Activin A human Recombinant produced in Nicotiana benthamiana plant is a disulfide-linked homodimers of two betaA chains, each containing 116 amino residues (molecular formula C600H911N173O174S13) and 6-His-tag at the N-terminal having the total molecular mass of 27.4kDa.

Recombinant Human Activin B Protein, His, Plant.-1mg

QP10504-1mg 1mg
EUR 6301.2

Recombinant Human Activin B Protein, His, Plant.-2ug

QP10504-2ug 2ug
EUR 186

Activin B Recombinant Protein

40-644 2 ug
EUR 311.1
Description: Activin B is a TGF-β family member that exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.

Recombinant Human Activin B Protein, His, Plant.-10ug

QP10504-10ug 10ug
EUR 241.2

Human Anti Activin A receptor antibody ELISA kit

E01A0725-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Anti Activin A receptor antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Anti Activin A receptor antibody ELISA kit

E01A0725-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Anti Activin A receptor antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Anti Activin A receptor antibody ELISA kit

E01A0725-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Anti Activin A receptor antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Anti Activin A receptor antibody ELISA kit

E01A0319 96T
EUR 700
Description: ELISA

Rat Activin B ELISA kit

E02A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E01A10291 96T
EUR 700
Description: ELISA

Goat Activin B ELISA kit

E06A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E01A45210 96T
EUR 700
Description: ELISA

Rat Activin B,ACV-B ELISA Kit

SL1430Ra - Ask for price

Mouse Activin B ELISA kit

E03A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Absence of YF-neutralizing antibodies in weak populations of Brazil: A warning for epidemiological surveillance and the potential dangers for future outbreaks

Yellow Fever (YF) is an acute febrile sickness brought on by yellow fever virus (YFV), a mosquito-borne flavivirus transmitted to people and non-human primates. In Brazil, YF is a public well being menace and will trigger recurrent epidemics, even with the provision of a vaccine.
We evaluated the sero-status for YFV in 581 people dwelling in a threat space for YF in Brazil. The realm presents historical past of instances and is situated within the southeast area of nation the place outbreaks of YF have been reported since 2016.
By means of, a PRNT assay, we discovered 25.8% of people missing YF-neutralizing antibodies. Moreover, neutralizing antibodies weren’t detected in 10 people with confirmed vaccination. Our findings reinforce the significance of surveillance methods and the necessity of an pressing intensification of immunization applications in areas with YFV circulation. Monitoring inclined people that might act as potential disseminators for YFV in threat areas also needs to be thought of.

Molecular and structural foundation for Lewis glycan recognition by a cancer-targeting antibody

Immunotherapy has been profitable in treating many tumour varieties. The event of further tumour-antigen binding monoclonal antibodies (mAbs) will assist broaden the vary of immunotherapeutic targets. Lewis histo-blood group and associated glycans are overexpressed on many carcinomas, together with these of the colon, lung, breast, prostate and ovary, and might subsequently be selectively focused by mAbs.
Right here we study the molecular and structural foundation for recognition of prolonged Lea and Lexcontaining glycans by a chimeric mAb. Each the murine (FG88.2) IgG3 and a chimeric (ch88.2) IgG1 mAb variants confirmed reactivity to colorectal most cancers cells resulting in considerably lowered cell viability. We decided the X-ray construction of the unliganded ch88.2 fragment antigen-binding (Fab) containing two Fabs within the unit cell.
A mix of molecular docking, glycan grafting and molecular dynamics simulations predicts two distinct subsites for recognition of Lea and Lex trisaccharides. Whereas gentle chain residues had been solely used for Lea binding, recognition of Lex concerned each gentle and heavy chain residues.
An prolonged groove is predicted to accommodate the Lea-Lex hexasaccharide with adjoining subsites for every trisaccharide. The molecular and structural particulars of the ch88.2 mAb offered right here present perception into its cross-reactivity for varied Lea and Lexcontaining glycans. Moreover, the anticipated interactions with prolonged epitopes possible explains the selectivity of this antibody for concentrating on Lewis-positive tumours.

TNFRSF25 Antibody

1-CSB-PA004866
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is Unconjugated. Tested in the following application: WB, ELISA;WB:1/500-1/2000.ELISA:1/20000

TNFRSF25 Antibody

1-CSB-PA213899
  • EUR 380.40
  • EUR 292.80
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, IHC;ELISA:1:1000-1:2000, IHC:1:10-1:50

TNFRSF25 Antibody

1-CSB-PA839000LA01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is Unconjugated. Tested in the following application: ELISA, WB; Recommended dilution: WB:1:1000-1:5000

TNFRSF25 Antibody

E035717 100μg/100μl
EUR 255
Description: Available in various conjugation types.

Recombinant Human TNFRSF25/DR3/TNFRSF12 Protein

RP00464 10 μg
EUR 208.8

Human TNFRSF25 Protein, Fc Tag

E40KMPH3481 20ug
EUR 495

Human TNFRSF25 Protein, Fc Tag

E40KMPH6417 20ug
EUR 495

Human TNFRSF25 Protein, Fc Tag

E40KMPH6545 20ug
EUR 495

Human TNFRSF25 knockout cell line

ABC-KH15847 1 vial Ask for price
Description: Human TNFRSF25 knockout cell line is HEK293/HeLa cell line, edited by CRISPR/Cas9 technology.

TNFRSF25 ORF Vector (Human) (pORF)

ORF014787 1.0 ug DNA
EUR 424.8

Human TNFRSF25 Protein Lysate 20ug

IHUTNFRSF25PLLY20UG each
EUR 213
Description: Human TNFRSF25 Protein Lysate 20ug

Human TNFRSF25 knockdown cell line

ABC-KD15847 1 vial Ask for price
Description: Human TNFRSF25 knockdown cell line is engineered by our optimized transduction of the specific shRNA with lentivirus. Knockdown levels are determined via qRT-PCR. Gentaur offers generation of stable knockdown (RNAi) cell lines expressing shRNAs targeting genes of your interest.

TNFRSF25 ELISA Kit (Human) (OKBB01104)

OKBB01104 96 Wells
EUR 606
Description: Description of target: Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. ;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

TNFRSF25 ELISA Kit (Human) (OKCA00847)

OKCA00847 96 Wells
EUR 999.6
Description: Description of target: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06 ng/mL

ELISA kit for Human TNFRSF25/DR3

EK5755 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human TNFRSF25/DR3 in samples from serum, plasma, tissue homogenates and other biological fluids.

TNFRSF25 siRNA

20-abx937612
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

Human TNFRSF25/DR3 PicoKine ELISA Kit

EK1579 96 wells
EUR 510
Description: For quantitative detection of human TNFRSF25 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Human DR3 / TNFRSF25 Protein, His Tag

TN5-H52H3 1mg
EUR 321
Description: Human DR3 / TNFRSF25, His Tag (TN5-H52H3) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Gln 199 (Accession # Q93038-1).

TNFRSF25 Conjugated Antibody

C35717 100ul
EUR 476.4

TNFRSF25 Monoclonal Antibody

E10-31965P 100μg/100μl
EUR 225
Description: Available in various conjugation types.

TNFRSF25 Monoclonal Antibody

E10-31966P 100μg/100μl
EUR 225
Description: Available in various conjugation types.

TNFRSF25 Polyclonal Antibody

E914261 100ul
EUR 225
Description: Available in various conjugation types.

Recombinant Human TNFRSF25/DR3/TNFRSF12 Protein, Fc His Tag

E40KMP1622 20ug
EUR 495

TNFRSF25 sgRNA CRISPR Lentivector set (Human)

K2416901 3 x 1.0 ug
EUR 406.8

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-1mg

QP7891-ec-1mg 1mg
EUR 1958.4

TNFRSF25 (untagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 2

SC109975 10 µg Ask for price

TNFRSF25 (untagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 12

SC310758 10 µg Ask for price

TNFRSF25 (untagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 1

SC306341 10 µg Ask for price

TNFRSF25 (untagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 3

SC306342 10 µg Ask for price

TNFRSF25 (untagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 4

SC306343 10 µg Ask for price

TNFRSF25 (untagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 7

SC306346 10 µg Ask for price

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-10ug

QP7891-ec-10ug 10ug
EUR 240

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-50ug

QP7891-ec-50ug 50ug
EUR 315.6

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-100ug

QP7891-ec-100ug 100ug
EUR 489.6

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-200ug

QP7891-ec-200ug 200ug
EUR 760.8

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-500ug

QP7891-ec-500ug 500ug
EUR 1272

TNFRSF25 Rabbit pAb

A14261-100ul 100 ul
EUR 369.6

TNFRSF25 Rabbit pAb

A14261-200ul 200 ul
EUR 550.8

TNFRSF25 Rabbit pAb

A14261-20ul 20 ul
EUR 219.6

TNFRSF25 Rabbit pAb

A14261-50ul 50 ul
EUR 267.6

TNFRSF25 Rabbit pAb

A9783-100ul 100 ul
EUR 369.6

TNFRSF25 Rabbit pAb

A9783-200ul 200 ul
EUR 550.8

TNFRSF25 Rabbit pAb

A9783-20ul 20 ul Ask for price

TNFRSF25 Rabbit pAb

A9783-50ul 50 ul Ask for price

TNFRSF25 Rabbit pAb

E2514261 100ul
EUR 225
Description: Available in various conjugation types.

TNFRSF25 Protein Vector (Human) (pPM-C-HA)

PV059147 500 ng
EUR 577.2

TNFRSF25 Protein Vector (Human) (pPB-C-His)

PV059145 500 ng
EUR 577.2

TNFRSF25 Protein Vector (Human) (pPB-N-His)

PV059146 500 ng
EUR 577.2

TNFRSF25 Protein Vector (Human) (pPM-C-His)

PV059148 500 ng
EUR 577.2

Polyclonal TNFRSF25 / DR3 Antibody

APR02680G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 . This antibody is tested and proven to work in the following applications:

Polyclonal TNFRSF25 / DR3 Antibody

APR02955G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 . This antibody is tested and proven to work in the following applications:

TNFRSF25 Antibody, HRP conjugated

1-CSB-PA839000LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

OPCA04539-1MG - TNFRSF25 Recombinant Protein (Human)

OPCA04539-1MG 1mg
EUR 1379

TNFRSF25 Antibody, FITC conjugated

1-CSB-PA839000LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

OACD00523-1ML - TNFRSF25 Antibody

OACD00523-1ML 1ml
EUR 729

TNFRSF25 (GFP-tagged) - Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 12

RG212175 10 µg Ask for price

TNFRSF25 (GFP-tagged) - Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 3

RG224211 10 µg Ask for price

TNFRSF25 (GFP-tagged) - Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 2

RG218838 10 µg Ask for price

TNFRSF25 (GFP-tagged) - Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 1

RG221420 10 µg Ask for price

TNFRSF25 (GFP-tagged) - Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 7

RG221479 10 µg Ask for price

TNFRSF25 (GFP-tagged) - Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 4

RG222367 10 µg Ask for price

OPCA04539-20UG - TNFRSF25 Recombinant Protein (Human)

OPCA04539-20UG 20ug
EUR 218

OPCA04539-100UG - TNFRSF25 Recombinant Protein (Human)

OPCA04539-100UG 100ug
EUR 323

TNFRSF25 cloning plasmid

CSB-CL839000HU-10ug 10ug
EUR 553.2
Description: A cloning plasmid for the TNFRSF25 gene.

Polyclonal TNFRSF25 Antibody (Center)

APR04205G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 (Center). This antibody is tested and proven to work in the following applications:

TNFRSF25 Antibody, Biotin conjugated

1-CSB-PA839000LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

OACD00523-100UL - TNFRSF25 Antibody

OACD00523-100UL 100ul
EUR 209

OAGA02588-100UL - TNFRSF25 Antibody

OAGA02588-100UL 100ul
EUR 369

TNFRSF25 Blocking Peptide

33R-3528 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TNFRSF25 antibody, catalog no. 70R-10465

TNFRSF25 sgRNA CRISPR Lentivector (Human) (Target 1)

K2416902 1.0 ug DNA
EUR 184.8

TNFRSF25 sgRNA CRISPR Lentivector (Human) (Target 2)

K2416903 1.0 ug DNA
EUR 184.8

TNFRSF25 sgRNA CRISPR Lentivector (Human) (Target 3)

K2416904 1.0 ug DNA
EUR 184.8

TNFRSF25 (Myc-DDK-tagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 12

RC212175 10 µg Ask for price

TNFRSF25 (Myc-DDK-tagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 1

RC221420 10 µg Ask for price

TNFRSF25 (Myc-DDK-tagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 7

RC221479 10 µg Ask for price

TNFRSF25 (Myc-DDK-tagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 4

RC222367 10 µg Ask for price

TNFRSF25 (Myc-DDK-tagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 3

RC224211 10 µg Ask for price

TNFRSF25 (Myc-DDK-tagged)-Human tumor necrosis factor receptor superfamily, member 25 (TNFRSF25), transcript variant 2

RC218838 10 µg Ask for price

TNFRSF25 (Center) Rabbit pAb

E2613483 100ul
EUR 225
Description: Available in various conjugation types.

Polyclonal TNFRSF25 antibody - middle region

APR01898G 0.05mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 - middle region. This antibody is tested and proven to work in the following applications:

DR3 / TNFRSF25 Recombinant Protein

96-794 0.1 mg
EUR 651.3
Description: Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

DR3 / TNFRSF25 Recombinant Protein

96-865 0.1 mg
EUR 651.3
Description: Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

Human TNF Receptor Superfamily Member 25 (TNFRSF25) ELISA Kit

abx259548-96tests 96 tests
EUR 1093.2

Tnfrsf25 (untagged) - Mouse tumor necrosis factor receptor superfamily, member 25 (Tnfrsf25), (10ug)

MC201299 10 µg Ask for price

Tnfrsf25 (GFP-tagged) - Mouse tumor necrosis factor receptor superfamily, member 25 (Tnfrsf25)

MG206521 10 µg Ask for price

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