Antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory

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A high-affinity antibody in opposition to the CSP N-terminal area lacks Plasmodium falciparum inhibitory exercise

 

Malaria is a worldwide well being concern, and analysis efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To information immunogen design, we search a complete understanding of the protecting humoral response in opposition to Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP).
In distinction to the well-studied responses to the repeat area and the C-terminus, the antibody response in opposition to the N-terminal area of PfCSP (N-CSP) stays obscure. Right here, we characterised the molecular recognition and useful efficacy of the N-CSP-specific monoclonal antibody 5D5.
The crystal construction at 1.85-Å decision revealed that 5D5 binds an α-helical epitope in N-CSP with excessive affinity via in depth form and cost complementarity and the bizarre utilization of an antibody N-linked glycan. Nonetheless, useful research indicated low 5D5 binding to reside Pf sporozoites and lack of sporozoite inhibition in vitro and in vivo. Total, our knowledge don’t assist the inclusion of the 5D5 N-CSP epitope into the following era of CSP-based vaccines.

Conjugation Website Influences Antibody-Conjugated Drug PK Assays: Case Research for Disulfide-Linked, Self-Immolating Subsequent–Technology Antibody Drug Conjugates

 

Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are broadly used within the area for antibody drug conjugates (ADCs) containing peptide linkers which can be enzymatically cleavable, similar to MC-ValCit-PAB. Conjugate PK assay methods for these ADCs contain cleavage with cathepsin B or papain to launch and measure the antibody-conjugated drug (acDrug) focus.
Nonetheless, sturdy acDrug PK strategies for disulfide-linked self-immolating ADCs are missing as they’re a distinct conjugation modality. We developed acDrug PK assays for next-generation disulfide-linked ADCs involving immunoaffinity seize, chemical cleavage, and LC-MS/MS.
Disulfide-linked ADCs captured from plasma had been chemically lowered at primary pH to launch the linker-drug, adopted by self-immolation to liberate the energetic drug, and quantified by MRM LC-MS/MS. Herein, we element the event and optimization of this chemical cleavage acDrug PK assay, leading to sturdy accuracy and precision (<u>+</u>20%).
The conjugation website of the linker-drug on the antibody was discovered to have an effect on the kinetics of drug launch. A number of biophysical and chemical traits, similar to tertiary construction, fractional solvent accessibility, pKa of the conjugation website, surrounding residue’s pI, and electrostatic cost, could immediately impression the drug launch kinetics. Comparable site-specific stability has been beforehand reported for ADCs in vivo.
The assay growth and qualification knowledge for this unique assay format are offered together with its utility to a number of in vitro and in vivo research throughout species.
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Human Activin B,ACV-B ELISA Kit
YLA4164HU-96T 96T
EUR 562.5

Recombinant Human Activin-B Active
7-00010 1ug Ask for price

Recombinant Human Activin-B Active
7-00011 5ug Ask for price

Recombinant Human Activin-B Active
7-00012 100µg Ask for price

Recombinant Human Activin-B, Plant
7-00013 2µg Ask for price

Recombinant Human Activin-B, Plant
7-00014 10µg Ask for price

Recombinant Human Activin-B, Plant
7-00015 1mg Ask for price

Recombinant Human Activin B Protein
PROTP09529-2 5ug
EUR 380.4
Description: Activin B is a TGF-β family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues. *Manufactured using BTI-Tn-5B1-4 cells under license from the Boyce Thompson Institute for Plant Research, Inc

Human Activin B (ACVB) CLIA Kit
abx196419-96tests 96 tests
EUR 990

Human Activin B (ACVB) CLIA Kit
20-abx491177
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Activin B, CF
PR15012CF 5 ug
EUR 451.2

Human Activin B ELISA Kit (ACVB)
RK00806 96 Tests
EUR 625.2

Human Activin B (ACVB) ELISA Kit
SEA170Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit
SEA170Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit
SEA170Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit
SEA170Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit
4-SEA170Hu
  • EUR 5188.80
  • EUR 2739.60
  • EUR 703.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Activin B (ACVB) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Activin B (INHBB) ELISA Kit
abx251961-96tests 96 tests
EUR 848.4

Human Activin B (INHBB) ELISA Kit
20-abx150537
  • EUR 7970.40
  • EUR 4250.40
  • EUR 990.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Activin-B Human Recombinant Protein
PROTP09529-1 Regular: 10ug
EUR 380.4
Description: Activin B human Recombinant produced in Nicotiana benthamiana plant is a beta-B single chain (aa 293-406) containing 123 amino acids (molecular formula C615H910N178O177S12). Activin B is fused to a 10-His-tag at the N-terminal having the total molecular mass of 14kDa and purified by standard chromatographic techniques.

Human ACVB(Activin B) ELISA Kit
EH2585 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Activin-B Protein
20-abx262336
  • EUR 393.60
  • EUR 7609.20
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Activin-B Human Recombinant Protein, Active
PROTP09529 Regular: 10ug
EUR 380.4
Description: Activin B human Recombinant produced in Nicotiana benthamiana plant is a beta-B single chain (aa 293-406) containing 123 amino acids (molecular formula C615H910N178O177S12). Activin B is fused to a 10-His-tag at the N-terminal having the total molecular mass of 14kDa and purified by standard chromatographic techniques.

CLIA kit for Human ACVB (Activin B)
E-CL-H0977 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human ACVB (Activin B) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human ACVB (Activin B)
E-EL-H1518 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human ACVB (Activin B) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human ACVB (Activin B)
ELK2858 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Activin B from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

Activin-B Active Protein
20-abx263007
  • EUR 393.60
  • EUR 8427.60
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Activin-A Activin A Human Recombinant Protein
PROTP08476-4 Regular: 10ug
EUR 380.4
Description: Activin-A Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 137 amino acids (311-426) and having a molecular mass of 15.2kDa.;Activin-A is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Activin B Recombinant Protein
40-644 2 ug
EUR 311.1
Description: Activin B is a TGF-β family member that exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.

Activin-A Activin A Human Recombinant Protein, Plant
PROTP08476 Regular: 10ug
EUR 380.4
Description: Activin A human Recombinant produced in Nicotiana benthamiana plant is a disulfide-linked homodimers of two betaA chains, each containing 116 amino residues (molecular formula C600H911N173O174S13) and 6-His-tag at the N-terminal having the total molecular mass of 27.4kDa.

Rat Activin B ELISA kit
E02A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit
E02A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit
E02A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit
E02A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit
E02A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit
E02A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit
E08A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit
E08A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit
E07A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit
E07A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit
E07A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit
E07A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit
E07A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit
E07A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit
E08A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit
E08A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit
E08A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit
E08A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit
E06A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit
E06A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit
E06A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit
E06A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit
E06A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit
E06A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Human Activin B Protein, His, Plant.-1mg
QP10504-1mg 1mg
EUR 6301.2

Recombinant Human Activin B Protein, His, Plant.-2ug
QP10504-2ug 2ug
EUR 186

Mouse Activin B ELISA kit
E03A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit
E03A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit
E03A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit
E03A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit
E03A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit
E03A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Human Activin B Protein, His, Plant.-10ug
QP10504-10ug 10ug
EUR 241.2

Mouse Activin B(ACV-B)ELISA Kit
CSB-E15932m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Activin B (ACV-B) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Activin B(ACV-B)ELISA Kit
1-CSB-E15932m
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Activin B(ACV-B) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rabbit Activin B ELISA kit
E04A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit
E04A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit
E04A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit
E04A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit
E04A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit
E04A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit
E09A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit
E09A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit
E09A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit
E09A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit
E09A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit
E09A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Anti Activin A receptor antibody ELISA kit
E01A0725-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Human Anti Activin A receptor antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Anti Activin A receptor antibody ELISA kit
E01A0725-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Human Anti Activin A receptor antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Anti Activin A receptor antibody ELISA kit
E01A0725-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Human Anti Activin A receptor antibody in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activin A Receptor Type I B (ACVR1B) Protein
20-abx065136
  • EUR 760.80
  • EUR 326.40
  • EUR 2281.20
  • EUR 895.20
  • EUR 543.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Recombinant Human Activin Receptor 2A/Activin RIIA/ACVR2A (C-6His)
C561-10ug 10ug
EUR 145.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Activin Receptor 2A/Activin RIIA/ACVR2A (C-6His)
C561-1mg 1mg
EUR 2739.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Activin Receptor 2A/Activin RIIA/ACVR2A (C-6His)
C561-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Activin Receptor 2A/Activin RIIA/ACVR2A (C-6His)
C561-50ug 50ug
EUR 315.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Activin Receptor 2B/Activin RIIB/ACVR2B (C-6His)
C302-10ug 10ug
EUR 120
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Activin Receptor 2B/Activin RIIB/ACVR2B (C-6His)
C302-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Activin Receptor 2B/Activin RIIB/ACVR2B (C-6His)
C302-500ug 500ug
EUR 1423.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Recombinant Human Activin Receptor 2B/Activin RIIB/ACVR2B (C-6His)
C302-50ug 50ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.4.

Rat Activin B (ACVB) CLIA Kit
20-abx490030
  • EUR 9493.20
  • EUR 5058.00
  • EUR 1167.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Absence of YF-neutralizing antibodies in weak populations of Brazil: A warning for epidemiological surveillance and the potential dangers for future outbreaks

Yellow Fever (YF) is an acute febrile sickness brought on by yellow fever virus (YFV), a mosquito-borne flavivirus transmitted to people and non-human primates. In Brazil, YF is a public well being menace and will trigger recurrent epidemics, even with the provision of a vaccine.
We evaluated the sero-status for YFV in 581 people dwelling in a threat space for YF in Brazil. The realm presents historical past of instances and is situated within the southeast area of nation the place outbreaks of YF have been reported since 2016.
By means of, a PRNT assay, we discovered 25.8% of people missing YF-neutralizing antibodies. Moreover, neutralizing antibodies weren’t detected in 10 people with confirmed vaccination. Our findings reinforce the significance of surveillance methods and the necessity of an pressing intensification of immunization applications in areas with YFV circulation. Monitoring inclined people that might act as potential disseminators for YFV in threat areas also needs to be thought of.

Molecular and structural foundation for Lewis glycan recognition by a cancer-targeting antibody

Immunotherapy has been profitable in treating many tumour varieties. The event of further tumour-antigen binding monoclonal antibodies (mAbs) will assist broaden the vary of immunotherapeutic targets. Lewis histo-blood group and associated glycans are overexpressed on many carcinomas, together with these of the colon, lung, breast, prostate and ovary, and might subsequently be selectively focused by mAbs.
Right here we study the molecular and structural foundation for recognition of prolonged Lea and Lexcontaining glycans by a chimeric mAb. Each the murine (FG88.2) IgG3 and a chimeric (ch88.2) IgG1 mAb variants confirmed reactivity to colorectal most cancers cells resulting in considerably lowered cell viability. We decided the X-ray construction of the unliganded ch88.2 fragment antigen-binding (Fab) containing two Fabs within the unit cell.
A mix of molecular docking, glycan grafting and molecular dynamics simulations predicts two distinct subsites for recognition of Lea and Lex trisaccharides. Whereas gentle chain residues had been solely used for Lea binding, recognition of Lex concerned each gentle and heavy chain residues.
An prolonged groove is predicted to accommodate the Lea-Lex hexasaccharide with adjoining subsites for every trisaccharide. The molecular and structural particulars of the ch88.2 mAb offered right here present perception into its cross-reactivity for varied Lea and Lexcontaining glycans. Moreover, the anticipated interactions with prolonged epitopes possible explains the selectivity of this antibody for concentrating on Lewis-positive tumours.

Recombinant Human TNFRSF25/DR3/TNFRSF12 Protein
RP00464 10 μg
EUR 208.8

TNFRSF25 ORF Vector (Human) (pORF)
ORF014787 1.0 ug DNA
EUR 424.8

TNFRSF25 siRNA
20-abx937612
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

TNFRSF25 ELISA Kit (Human) (OKBB01104)
OKBB01104 96 Wells
EUR 606
Description: Description of target: Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. ;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

TNFRSF25 ELISA Kit (Human) (OKCA00847)
OKCA00847 96 Wells
EUR 999.6
Description: Description of target: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06 ng/mL

ELISA kit for Human TNFRSF25/DR3
EK5755 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human TNFRSF25/DR3 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human TNFRSF25/DR3 PicoKine ELISA Kit
EK1579 96 wells
EUR 510
Description: For quantitative detection of human TNFRSF25 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

TNFRSF25 Conjugated Antibody
C35717 100ul
EUR 476.4

TNFRSF25 Rabbit pAb
A14261-100ul 100 ul
EUR 369.6

TNFRSF25 Rabbit pAb
A14261-200ul 200 ul
EUR 550.8

TNFRSF25 Rabbit pAb
A14261-20ul 20 ul
EUR 219.6

TNFRSF25 Rabbit pAb
A14261-50ul 50 ul
EUR 267.6

TNFRSF25 Rabbit pAb
A9783-100ul 100 ul
EUR 369.6

TNFRSF25 Rabbit pAb
A9783-200ul 200 ul
EUR 550.8

TNFRSF25 Rabbit pAb
A9783-20ul 20 ul Ask for price

TNFRSF25 Rabbit pAb
A9783-50ul 50 ul Ask for price

TNFRSF25 sgRNA CRISPR Lentivector set (Human)
K2416901 3 x 1.0 ug
EUR 406.8

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-1mg
QP7891-ec-1mg 1mg
EUR 1958.4

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-10ug
QP7891-ec-10ug 10ug
EUR 240

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-50ug
QP7891-ec-50ug 50ug
EUR 315.6

Polyclonal TNFRSF25 / DR3 Antibody
APR02680G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 . This antibody is tested and proven to work in the following applications:

Polyclonal TNFRSF25 / DR3 Antibody
APR02955G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 . This antibody is tested and proven to work in the following applications:

TNFRSF25 Antibody, HRP conjugated
1-CSB-PA839000LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-100ug
QP7891-ec-100ug 100ug
EUR 489.6

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-200ug
QP7891-ec-200ug 200ug
EUR 760.8

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-500ug
QP7891-ec-500ug 500ug
EUR 1272

TNFRSF25 cloning plasmid
CSB-CL839000HU-10ug 10ug
EUR 553.2
Description: A cloning plasmid for the TNFRSF25 gene.

TNFRSF25 Antibody, FITC conjugated
1-CSB-PA839000LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

TNFRSF25 Protein Vector (Human) (pPM-C-HA)
PV059147 500 ng
EUR 577.2

TNFRSF25 Blocking Peptide
33R-3528 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TNFRSF25 antibody, catalog no. 70R-10465

TNFRSF25 Protein Vector (Human) (pPB-C-His)
PV059145 500 ng
EUR 577.2

TNFRSF25 Protein Vector (Human) (pPB-N-His)
PV059146 500 ng
EUR 577.2

TNFRSF25 Protein Vector (Human) (pPM-C-His)
PV059148 500 ng
EUR 577.2

Polyclonal TNFRSF25 Antibody (Center)
APR04205G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 (Center). This antibody is tested and proven to work in the following applications:

TNFRSF25 Antibody, Biotin conjugated
1-CSB-PA839000LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

TNFRSF25 sgRNA CRISPR Lentivector (Human) (Target 1)
K2416902 1.0 ug DNA
EUR 184.8

TNFRSF25 sgRNA CRISPR Lentivector (Human) (Target 2)
K2416903 1.0 ug DNA
EUR 184.8

TNFRSF25 sgRNA CRISPR Lentivector (Human) (Target 3)
K2416904 1.0 ug DNA
EUR 184.8

DR3 / TNFRSF25 Recombinant Protein
96-794 0.1 mg
EUR 651.3
Description: Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

DR3 / TNFRSF25 Recombinant Protein
96-865 0.1 mg
EUR 651.3
Description: Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

Polyclonal TNFRSF25 antibody - middle region
APR01898G 0.05mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 - middle region. This antibody is tested and proven to work in the following applications:

Tnfrsf25 ORF Vector (Rat) (pORF)
ORF078025 1.0 ug DNA
EUR 607.2

Tnfrsf25 ORF Vector (Mouse) (pORF)
ORF060084 1.0 ug DNA
EUR 607.2

Human TNF Receptor Superfamily Member 25 (TNFRSF25) ELISA Kit
abx259548-96tests 96 tests
EUR 1093.2

Polyclonal TNFRSF25 / DR3 Antibody (aa25-40)
APR02519G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 (aa25-40). This antibody is tested and proven to work in the following applications:

Recombinant Human Death Receptor 3/DR3/TNFRSF25 (C-Fc)
CJ74-10ug 10ug
EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Death Receptor 3/DR3/TNFRSF25 (C-Fc)
CJ74-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Death Receptor 3/DR3/TNFRSF25 (C-Fc)
CJ74-500ug 500ug
EUR 1338
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Death Receptor 3/DR3/TNFRSF25 (C-Fc)
CJ74-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

TNFRSF25 ELISA Kit (Mouse) (OKBB01049)
OKBB01049 96 Wells
EUR 606
Description: Description of target: Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. ;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <15pg/ml

ELISA kit for Mouse TNFRSF25/DR3
EK5714 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse TNFRSF25/DR3 in samples from serum, plasma, tissue homogenates and other biological fluids.

Polyclonal TNFRSF25 / DR3 Antibody (Extracellular Domain)
APR02518G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 (Extracellular Domain). This antibody is tested and proven to work in the following applications:

Human Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)
1-CSB-EP839000HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Tumor necrosis factor receptor superfamily member 25(TNFRSF25),partial expressed in E.coli

Mouse TNFRSF25/DR3 PicoKine ELISA Kit
EK1515 96 wells
EUR 510
Description: For quantitative detection of mouse TNFRSF25 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

TNFRSF25 sgRNA CRISPR/Cas9 All-in-One Lentivector set (Human)
K2416905 3 x 1.0 ug
EUR 451.2

TNF Receptor Superfamily Member 25 (TNFRSF25) Antibody
abx412445-01mg 0.1 mg
EUR 610.8

TNF Receptor Superfamily Member 25 (TNFRSF25) Antibody
abx412446-01mg 0.1 mg
EUR 610.8

TNFRSF25 3'UTR GFP Stable Cell Line
TU076030 1.0 ml
EUR 1825.2

Tnfrsf25 3'UTR GFP Stable Cell Line
TU170889 1.0 ml Ask for price

Tnfrsf25 3'UTR GFP Stable Cell Line
TU272242 1.0 ml Ask for price

Tnfrsf25 sgRNA CRISPR Lentivector set (Rat)
K6493001 3 x 1.0 ug
EUR 406.8

Monoclonal TNFRSF25 Antibody (monoclonal) (M06), Clone: 4E4
AMM04216G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human TNFRSF25 (monoclonal) (M06). The antibodies are raised in mouse and are from clone 4E4. This antibody is applicable in WB, E

Tnfrsf25 sgRNA CRISPR Lentivector set (Mouse)
K3774801 3 x 1.0 ug
EUR 406.8

TNFRSF25 Protein Vector (Rat) (pPM-C-HA)
PV312100 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Rat) (pPB-C-His)
PV312098 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Rat) (pPB-N-His)
PV312099 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Rat) (pPM-C-His)
PV312101 500 ng
EUR 723.6

TNFRSF25 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
K2416906 1.0 ug DNA
EUR 200.4

TNFRSF25 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 2)
K2416907 1.0 ug DNA
EUR 200.4

TNFRSF25 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 3)
K2416908 1.0 ug DNA
EUR 200.4

TNFRSF25 TNF Ligand Receptor Superfamily Member 25 Recombinant Protein Human
PROTQ93038 Regular: 5ug
EUR 380.4
Description: TNFRSF25 Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 417 amino acids (25-199) and having a molecular mass of 46.1kDa (Molecular size on SDS-PAGE will appear at approximately 40-57kDa). TNFRSF25 is fused to a 242 amino acid IgG His-Tag at C-terminus and purified by proprietary chromatographic techniques.

TNFRSF25 Protein Vector (Mouse) (pPM-C-HA)
PV240336 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Mouse) (pPB-C-His)
PV240334 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Mouse) (pPB-N-His)
PV240335 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Mouse) (pPM-C-His)
PV240337 500 ng
EUR 723.6

Tnfrsf25 3'UTR Luciferase Stable Cell Line
TU120889 1.0 ml Ask for price

TNFRSF25 3'UTR Luciferase Stable Cell Line
TU026030 1.0 ml
EUR 1825.2

Tnfrsf25 3'UTR Luciferase Stable Cell Line
TU222242 1.0 ml Ask for price

Tnfrsf25 sgRNA CRISPR Lentivector (Rat) (Target 1)
K6493002 1.0 ug DNA
EUR 184.8

Tnfrsf25 sgRNA CRISPR Lentivector (Rat) (Target 2)
K6493003 1.0 ug DNA
EUR 184.8

Tnfrsf25 sgRNA CRISPR Lentivector (Rat) (Target 3)
K6493004 1.0 ug DNA
EUR 184.8

Human Tumor necrosis factor receptor superfamily member 25(TNFRSF25) ELISA kit
CSB-EL023980HU-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Tumor necrosis factor receptor superfamily member 25(TNFRSF25) ELISA kit
1-CSB-EL023980HU
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Tumor necrosis factor receptor superfamily member 25(TNFRSF25) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Tnfrsf25 sgRNA CRISPR Lentivector (Mouse) (Target 1)
K3774802 1.0 ug DNA
EUR 184.8

Tnfrsf25 sgRNA CRISPR Lentivector (Mouse) (Target 2)
K3774803 1.0 ug DNA
EUR 184.8

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