Antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory

controlpeptidecomprimary

A high-affinity antibody in opposition to the CSP N-terminal area lacks Plasmodium falciparum inhibitory exercise

 

Malaria is a worldwide well being concern, and analysis efforts are ongoing to develop a superior vaccine to RTS,S/AS01. To information immunogen design, we search a complete understanding of the protecting humoral response in opposition to Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP).
In distinction to the well-studied responses to the repeat area and the C-terminus, the antibody response in opposition to the N-terminal area of PfCSP (N-CSP) stays obscure. Right here, we characterised the molecular recognition and useful efficacy of the N-CSP-specific monoclonal antibody 5D5.
The crystal construction at 1.85-Å decision revealed that 5D5 binds an α-helical epitope in N-CSP with excessive affinity via in depth form and cost complementarity and the bizarre utilization of an antibody N-linked glycan. Nonetheless, useful research indicated low 5D5 binding to reside Pf sporozoites and lack of sporozoite inhibition in vitro and in vivo. Total, our knowledge don’t assist the inclusion of the 5D5 N-CSP epitope into the following era of CSP-based vaccines.

Conjugation Website Influences Antibody-Conjugated Drug PK Assays: Case Research for Disulfide-Linked, Self-Immolating SubsequentTechnology Antibody Drug Conjugates

 

Immunoaffinity (IA) LC-MS/MS pharmacokinetic (PK) assays are broadly used within the area for antibody drug conjugates (ADCs) containing peptide linkers which can be enzymatically cleavable, similar to MC-ValCit-PAB. Conjugate PK assay methods for these ADCs contain cleavage with cathepsin B or papain to launch and measure the antibody-conjugated drug (acDrug) focus.
Nonetheless, sturdy acDrug PK strategies for disulfide-linked self-immolating ADCs are missing as they’re a distinct conjugation modality. We developed acDrug PK assays for next-generation disulfide-linked ADCs involving immunoaffinity seize, chemical cleavage, and LC-MS/MS.
Disulfide-linked ADCs captured from plasma had been chemically lowered at primary pH to launch the linker-drug, adopted by self-immolation to liberate the energetic drug, and quantified by MRM LC-MS/MS. Herein, we element the event and optimization of this chemical cleavage acDrug PK assay, leading to sturdy accuracy and precision (<u>+</u>20%).
The conjugation website of the linker-drug on the antibody was discovered to have an effect on the kinetics of drug launch. A number of biophysical and chemical traits, similar to tertiary construction, fractional solvent accessibility, pKa of the conjugation website, surrounding residue’s pI, and electrostatic cost, could immediately impression the drug launch kinetics. Comparable site-specific stability has been beforehand reported for ADCs in vivo.
The assay growth and qualification knowledge for this unique assay format are offered together with its utility to a number of in vitro and in vivo research throughout species.
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controlpeptidecomprimary

Human Activin B ELISA kit

E01A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Human Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activin B ELISA kit

E01A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Human Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Activin B ELISA kit

E01A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Human Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Recombinant Human Activin-B Active

7-00010 1ug Ask for price

Recombinant Human Activin-B Active

7-00011 5ug Ask for price

Recombinant Human Activin-B Active

7-00012 100µg Ask for price

Recombinant Human Activin-B, Plant

7-00013 2µg Ask for price

Recombinant Human Activin-B, Plant

7-00014 10µg Ask for price

Recombinant Human Activin-B, Plant

7-00015 1mg Ask for price

Activin-B Human Recombinant Protein

PROTP09529-1 Regular: 10ug
EUR 380.4
Description: Activin B human Recombinant produced in Nicotiana benthamiana plant is a beta-B single chain (aa 293-406) containing 123 amino acids (molecular formula C615H910N178O177S12). Activin B is fused to a 10-His-tag at the N-terminal having the total molecular mass of 14kDa and purified by standard chromatographic techniques.

Recombinant Human Activin B Protein

PROTP09529-2 5ug
EUR 380.4
Description: Activin B is a TGF-β family member that exhibits a wide range of biological activities including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues. *Manufactured using BTI-Tn-5B1-4 cells under license from the Boyce Thompson Institute for Plant Research, Inc

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 418.8

Activin B Recombinant Protein

40-644 2 ug
EUR 311.1
Description: Activin B is a TGF-β family member that exhibits a wide range of biological activities, including regulation of embryogenesis, osteogenesis, hematopoiesis, reproductive physiology and hormone secretion from the hypothalamic, pituitary and gonadal glands. Activin B, like certain other members of the TGF-β family, signals through the ActRII receptor (Activin Receptor type II). Activins are homodimers or heterodimers of different β subunits. They are produced as precursor proteins with an amino terminal propeptide that is cleaved to release the C-terminal bioactive ligand. Human Activin B is a 25.6 kDa disulfide-linked homodimer consisting of two βB chains, each containing 115 amino acid residues.

Activin-B Active Protein

20-abx263007
  • EUR 393.60
  • EUR 8427.60
  • EUR 276.00
  • 10 ug
  • 1 mg
  • 2 µg

Human ACVB(Activin B) ELISA Kit

EH2585 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 9.375pg/ml

Human Activin B (INHBB) ELISA Kit

20-abx150537
  • EUR 7970.40
  • EUR 4250.40
  • EUR 990.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Activin B (ACVB) CLIA Kit

abx196419-96tests 96 tests
EUR 990

Human Activin B (ACVB) CLIA Kit

20-abx491177
  • EUR 9567.60
  • EUR 5095.20
  • EUR 1177.20
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Activin B (INHBB) ELISA Kit

abx251961-96tests 96 tests
EUR 848.4

Activin-B Human Recombinant Protein, Active

PROTP09529 Regular: 10ug
EUR 380.4
Description: Activin B human Recombinant produced in Nicotiana benthamiana plant is a beta-B single chain (aa 293-406) containing 123 amino acids (molecular formula C615H910N178O177S12). Activin B is fused to a 10-His-tag at the N-terminal having the total molecular mass of 14kDa and purified by standard chromatographic techniques.

Human Activin B (ACVB) ELISA Kit

SEA170Hu-10x96wellstestplate 10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit

SEA170Hu-1x48wellstestplate 1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit

SEA170Hu-1x96wellstestplate 1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit

SEA170Hu-5x96wellstestplate 5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Activin B (ACVB) ELISA Kit

4-SEA170Hu
  • EUR 5188.80
  • EUR 2739.60
  • EUR 703.20
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Activin B (ACVB) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Human Activin B ELISA Kit (ACVB)

RK00806 96 Tests
EUR 625.2

Mouse Activin B(ACV-B)ELISA Kit

CSB-E15932m-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Mouse Activin B (ACV-B) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Mouse Activin B(ACV-B)ELISA Kit

1-CSB-E15932m
  • EUR 964.80
  • EUR 6118.80
  • EUR 3244.80
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Mouse Activin B(ACV-B) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Rat Activin B ELISA kit

E02A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B ELISA kit

E02A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Activin B ELISA kit

E07A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Porcine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Activin B ELISA kit

E08A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Canine Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit

E09A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit

E09A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit

E09A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit

E09A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit

E09A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Activin B ELISA kit

E09A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Monkey Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Activin B ELISA kit

E03A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Mouse Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Activin B ELISA kit

E06A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Goat Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit

E04A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit

E04A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit

E04A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit

E04A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit

E04A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Activin B ELISA kit

E04A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Rabbit Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

ELISA kit for Human ACVB (Activin B)

E-EL-H1518 1 plate of 96 wells
EUR 640.8
Description: A sandwich ELISA kit for quantitative measurement of Human ACVB (Activin B) in samples from Serum, Plasma, Cell supernatant

CLIA kit for Human ACVB (Activin B)

E-CL-H0977 1 plate of 96 wells
EUR 700.8
Description: A sandwich CLIA kit for quantitative measurement of Human ACVB (Activin B) in samples from Serum, Plasma, Cell supernatant

ELISA kit for Human ACVB (Activin B)

ELK2858 1 plate of 96 wells
EUR 518.4
Description: A sandwich ELISA kit for detection of Activin B from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids.

ELISA kit for Mouse Activin B (ACV-B)

KTE70548-48T 48T
EUR 398.4
Description: Quantitative sandwich ELISA for measuring Mouse Activin B (ACV-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Activin B (ACV-B)

KTE70548-5platesof96wells 5 plates of 96 wells
EUR 2538
Description: Quantitative sandwich ELISA for measuring Mouse Activin B (ACV-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Mouse Activin B (ACV-B)

KTE70548-96T 96T
EUR 646.8
Description: Quantitative sandwich ELISA for measuring Mouse Activin B (ACV-B) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Rat Activin B (ACVB) ELISA Kit

CEA170Ra-10x96wellstestplate 10x96-wells test plate
EUR 5552.14
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Activin B (ACVB) ELISA Kit

CEA170Ra-1x48wellstestplate 1x48-wells test plate
EUR 562.42
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Activin B (ACVB) ELISA Kit

CEA170Ra-1x96wellstestplate 1x96-wells test plate
EUR 752.02
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Activin B (ACVB) ELISA Kit

CEA170Ra-5x96wellstestplate 5x96-wells test plate
EUR 3024.07
Description: This is Competitive Enzyme-linked immunosorbent assay for detection of Rat Activin B (ACVB) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Rat Activin B (ACVB) ELISA Kit

4-CEA170Ra
  • EUR 5612.40
  • EUR 2965.20
  • EUR 752.40
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Competitive Inhibition method for detection of Rat Activin B (ACVB) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids with no significant corss-reactivity with analogues from other species.

Guinea pig Activin B ELISA kit

E05A2150-192T 192 tests
EUR 1524
Description: A competitive for quantitative measurement of Guinea pig Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Activin B ELISA kit

E05A2150-48 1 plate of 48 wells
EUR 624
Description: A competitive for quantitative measurement of Guinea pig Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Activin B ELISA kit

E05A2150-96 1 plate of 96 wells
EUR 822
Description: A competitive for quantitative measurement of Guinea pig Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Activin B ELISA kit

E05A4008-192T 192 tests
EUR 1524
Description: A sandwich ELISA for quantitative measurement of Guinea pig Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Activin B ELISA kit

E05A4008-48 1 plate of 48 wells
EUR 624
Description: A sandwich ELISA for quantitative measurement of Guinea pig Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Activin B ELISA kit

E05A4008-96 1 plate of 96 wells
EUR 822
Description: A sandwich ELISA for quantitative measurement of Guinea pig Activin B in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Activin B (INHBB) ELISA Kit

20-abx156914
  • EUR 8684.40
  • EUR 4626.00
  • EUR 1074.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Rat Activin B (ACVB) CLIA Kit

20-abx490030
  • EUR 9493.20
  • EUR 5058.00
  • EUR 1167.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Sheep Activin B (INHBB) ELISA Kit

abx257397-96tests 96 tests
EUR 990

Absence of YF-neutralizing antibodies in weak populations of Brazil: A warning for epidemiological surveillance and the potential dangers for future outbreaks

Yellow Fever (YF) is an acute febrile sickness brought on by yellow fever virus (YFV), a mosquito-borne flavivirus transmitted to people and non-human primates. In Brazil, YF is a public well being menace and will trigger recurrent epidemics, even with the provision of a vaccine.
We evaluated the sero-status for YFV in 581 people dwelling in a threat space for YF in Brazil. The realm presents historical past of instances and is situated within the southeast area of nation the place outbreaks of YF have been reported since 2016.
By means of, a PRNT assay, we discovered 25.8% of people missing YF-neutralizing antibodies. Moreover, neutralizing antibodies weren’t detected in 10 people with confirmed vaccination. Our findings reinforce the significance of surveillance methods and the necessity of an pressing intensification of immunization applications in areas with YFV circulation. Monitoring inclined people that might act as potential disseminators for YFV in threat areas also needs to be thought of.

Molecular and structural foundation for Lewis glycan recognition by a cancer-targeting antibody

Immunotherapy has been profitable in treating many tumour varieties. The event of further tumour-antigen binding monoclonal antibodies (mAbs) will assist broaden the vary of immunotherapeutic targets. Lewis histo-blood group and associated glycans are overexpressed on many carcinomas, together with these of the colon, lung, breast, prostate and ovary, and might subsequently be selectively focused by mAbs.
Right here we study the molecular and structural foundation for recognition of prolonged Lea and Lexcontaining glycans by a chimeric mAb. Each the murine (FG88.2) IgG3 and a chimeric (ch88.2) IgG1 mAb variants confirmed reactivity to colorectal most cancers cells resulting in considerably lowered cell viability. We decided the X-ray construction of the unliganded ch88.2 fragment antigen-binding (Fab) containing two Fabs within the unit cell.
A mix of molecular docking, glycan grafting and molecular dynamics simulations predicts two distinct subsites for recognition of Lea and Lex trisaccharides. Whereas gentle chain residues had been solely used for Lea binding, recognition of Lex concerned each gentle and heavy chain residues.
An prolonged groove is predicted to accommodate the Lea-Lex hexasaccharide with adjoining subsites for every trisaccharide. The molecular and structural particulars of the ch88.2 mAb offered right here present perception into its cross-reactivity for varied Lea and Lexcontaining glycans. Moreover, the anticipated interactions with prolonged epitopes possible explains the selectivity of this antibody for concentrating on Lewis-positive tumours.

TNFRSF25 antibody

70R-10465 50 ug
EUR 560.4
Description: Affinity purified rabbit polyclonal TNFRSF25 antibody

TNFRSF25 Antibody

35717-100ul 100ul
EUR 302.4

Human TNFRSF25 shRNA Plasmid

20-abx955739
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

Human TNFRSF25 ELISA KIT

ELI-40008h 96 Tests
EUR 988.8

TNFRSF25 Conjugated Antibody

C35717 100ul
EUR 476.4

TNFRSF25 cloning plasmid

CSB-CL839000HU-10ug 10ug
EUR 553.2
Description: A cloning plasmid for the TNFRSF25 gene.

TNFRSF25 Rabbit pAb

A14261-100ul 100 ul
EUR 369.6

TNFRSF25 Rabbit pAb

A14261-200ul 200 ul
EUR 550.8

TNFRSF25 Rabbit pAb

A14261-20ul 20 ul
EUR 219.6

TNFRSF25 Rabbit pAb

A14261-50ul 50 ul
EUR 267.6

TNFRSF25 Blocking Peptide

33R-3528 100 ug
EUR 216
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of TNFRSF25 antibody, catalog no. 70R-10465

TNFRSF25 Rabbit pAb

A9783-100ul 100 ul
EUR 369.6

TNFRSF25 Rabbit pAb

A9783-200ul 200 ul
EUR 550.8

TNFRSF25 Rabbit pAb

A9783-20ul 20 ul Ask for price

TNFRSF25 Rabbit pAb

A9783-50ul 50 ul Ask for price

pDONR223-TNFRSF25 Plasmid

PVTB01130-1 2 ug
EUR 427.2

TNFRSF25 ELISA Kit (Human) (OKBB01104)

OKBB01104 96 Wells
EUR 606
Description: Description of target: Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. ;Species reactivity: Human;Application: ELISA;Assay info: ;Sensitivity: <10pg/ml

TNFRSF25 ELISA Kit (Human) (OKCA00847)

OKCA00847 96 Wells
EUR 999.6
Description: Description of target: Receptor for TNFSF12/APO3L/TWEAK. Interacts directly with the adapter TRADD. Mediates activation of NF-kappa-B and induces apoptosis. May play a role in regulating lymphocyte homeostasis. ;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 0.06 ng/mL

TNFRSF25 ORF Vector (Human) (pORF)

ORF014787 1.0 ug DNA
EUR 424.8

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 336

TNFRSF25 Antibody, HRP conjugated

1-CSB-PA839000LB01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is HRP conjugated. Tested in the following application: ELISA

TNFRSF25 Antibody, FITC conjugated

1-CSB-PA839000LC01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is FITC conjugated. Tested in the following application: ELISA

TNFRSF25 Antibody, Biotin conjugated

1-CSB-PA839000LD01HU
  • EUR 380.40
  • EUR 402.00
  • 100ul
  • 50ul
Description: A polyclonal antibody against TNFRSF25. Recognizes TNFRSF25 from Human. This antibody is Biotin conjugated. Tested in the following application: ELISA

DR3 / TNFRSF25 Recombinant Protein

96-794 0.1 mg
EUR 651.3
Description: Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

DR3 / TNFRSF25 Recombinant Protein

96-865 0.1 mg
EUR 651.3
Description: Tumor necrosis factor receptor superfamily member 25 (TNFRSF25) is also known as Apo-3, Death receptor 3 (DDR3 or DR3), Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor TRAMP, Lymphocyte-associated receptor of death, Apo-3, which is a member of the TNF-receptor superfamily. TNFRSF25 is a homodimer protein, which can Interact strongly via the death domains with TNFRSF1 and TRADD to activate at least two distinct signaling cascades, apoptosis and NF-kappa-B signaling. TNFRSF25 is receptor for TNFSF12 / APO3L / TWEAK.

Polyclonal TNFRSF25 / DR3 Antibody

APR02680G 0.05ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 . This antibody is tested and proven to work in the following applications:

Polyclonal TNFRSF25 / DR3 Antibody

APR02955G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 . This antibody is tested and proven to work in the following applications:

Polyclonal TNFRSF25 Antibody (Center)

APR04205G 0.1ml
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 (Center). This antibody is tested and proven to work in the following applications:

Human TNFRSF25/DR3 PicoKine ELISA Kit

EK1579 96 wells
EUR 510
Description: For quantitative detection of human TNFRSF25 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

ELISA kit for Human TNFRSF25/DR3

EK5755 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Human TNFRSF25/DR3 in samples from serum, plasma, tissue homogenates and other biological fluids.

TNFRSF25 sgRNA CRISPR Lentivector set (Human)

K2416901 3 x 1.0 ug
EUR 406.8

Recombinant Human TNFRSF25/DR3/TNFRSF12 Protein

RP00464 10 μg
EUR 208.8

TNFRSF25 sgRNA CRISPR Lentivector (Human) (Target 1)

K2416902 1.0 ug DNA
EUR 184.8

TNFRSF25 sgRNA CRISPR Lentivector (Human) (Target 2)

K2416903 1.0 ug DNA
EUR 184.8

TNFRSF25 sgRNA CRISPR Lentivector (Human) (Target 3)

K2416904 1.0 ug DNA
EUR 184.8

TNFRSF25 Protein Vector (Human) (pPB-C-His)

PV059145 500 ng
EUR 577.2

TNFRSF25 Protein Vector (Human) (pPB-N-His)

PV059146 500 ng
EUR 577.2

TNFRSF25 Protein Vector (Human) (pPM-C-HA)

PV059147 500 ng
EUR 577.2

TNFRSF25 Protein Vector (Human) (pPM-C-His)

PV059148 500 ng
EUR 577.2

Polyclonal TNFRSF25 antibody - middle region

APR01898G 0.05mg
EUR 633.6
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 - middle region. This antibody is tested and proven to work in the following applications:

TNFRSF25 ELISA Kit (Mouse) (OKBB01049)

OKBB01049 96 Wells
EUR 606
Description: Description of target: Death receptor 3 (DR3), also known as tumor necrosis factor receptor superfamily member 25 (TNFRSF25), is a cell surface receptor of the tumor necrosis factor receptor superfamily which mediates apoptotic signalling and differentiation. Knockout studies in mice suggested the role of this gene in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation. ;Species reactivity: Mouse;Application: ELISA;Assay info: ;Sensitivity: <15pg/ml

Tnfrsf25 ORF Vector (Rat) (pORF)

ORF078025 1.0 ug DNA
EUR 607.2

Tnfrsf25 ORF Vector (Mouse) (pORF)

ORF060084 1.0 ug DNA
EUR 607.2

Mouse TNFRSF25/DR3 PicoKine ELISA Kit

EK1515 96 wells
EUR 510
Description: For quantitative detection of mouse TNFRSF25 in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

ELISA kit for Mouse TNFRSF25/DR3

EK5714 96 tests
EUR 663.6
Description: Enzyme-linked immunosorbent assay kit for quantification of Mouse TNFRSF25/DR3 in samples from serum, plasma, tissue homogenates and other biological fluids.

Polyclonal TNFRSF25 / DR3 Antibody (Extracellular Domain)

APR02518G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 (Extracellular Domain). This antibody is tested and proven to work in the following applications:

Polyclonal TNFRSF25 / DR3 Antibody (aa25-40)

APR02519G 0.05mg
EUR 580.8
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human TNFRSF25 / DR3 (aa25-40). This antibody is tested and proven to work in the following applications:

Tnfrsf25 sgRNA CRISPR Lentivector set (Mouse)

K3774801 3 x 1.0 ug
EUR 406.8

Tnfrsf25 sgRNA CRISPR Lentivector set (Rat)

K6493001 3 x 1.0 ug
EUR 406.8

Recombinant Human Death Receptor 3/DR3/TNFRSF25 (C-Fc)

CJ74-10ug 10ug
EUR 169.2
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Death Receptor 3/DR3/TNFRSF25 (C-Fc)

CJ74-1mg 1mg
EUR 2008.8
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Death Receptor 3/DR3/TNFRSF25 (C-Fc)

CJ74-500ug 500ug
EUR 1338
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Human Death Receptor 3/DR3/TNFRSF25 (C-Fc)

CJ74-50ug 50ug
EUR 363.6
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Human Tumor necrosis factor receptor superfamily member 25 (TNFRSF25)

1-CSB-EP839000HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Tumor necrosis factor receptor superfamily member 25(TNFRSF25),partial expressed in E.coli

Human TNF Receptor Superfamily Member 25 (TNFRSF25) ELISA Kit

abx259548-96tests 96 tests
EUR 1093.2

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-100ug

QP7891-ec-100ug 100ug
EUR 489.6

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-10ug

QP7891-ec-10ug 10ug
EUR 240

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-1mg

QP7891-ec-1mg 1mg
EUR 1958.4

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-200ug

QP7891-ec-200ug 200ug
EUR 760.8

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-500ug

QP7891-ec-500ug 500ug
EUR 1272

Recombinant Human TNFRSF25/ DR3/ TNFRSF12 Protein, His, E.coli-50ug

QP7891-ec-50ug 50ug
EUR 315.6

TNF Receptor Superfamily Member 25 (TNFRSF25) Antibody

abx412445-01mg 0.1 mg
EUR 610.8

TNF Receptor Superfamily Member 25 (TNFRSF25) Antibody

abx412446-01mg 0.1 mg
EUR 610.8

Monoclonal TNFRSF25 Antibody (monoclonal) (M06), Clone: 4E4

AMM04216G 0.1mg
EUR 580.8
Description: A Monoclonal antibody against Human TNFRSF25 (monoclonal) (M06). The antibodies are raised in mouse and are from clone 4E4. This antibody is applicable in WB, E

Tnfrsf25 sgRNA CRISPR Lentivector (Mouse) (Target 1)

K3774802 1.0 ug DNA
EUR 184.8

Tnfrsf25 sgRNA CRISPR Lentivector (Mouse) (Target 2)

K3774803 1.0 ug DNA
EUR 184.8

Tnfrsf25 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K3774804 1.0 ug DNA
EUR 184.8

Tnfrsf25 sgRNA CRISPR Lentivector (Rat) (Target 1)

K6493002 1.0 ug DNA
EUR 184.8

Tnfrsf25 sgRNA CRISPR Lentivector (Rat) (Target 2)

K6493003 1.0 ug DNA
EUR 184.8

Tnfrsf25 sgRNA CRISPR Lentivector (Rat) (Target 3)

K6493004 1.0 ug DNA
EUR 184.8

TNFRSF25 Protein Vector (Rat) (pPB-C-His)

PV312098 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Rat) (pPB-N-His)

PV312099 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Rat) (pPM-C-HA)

PV312100 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Rat) (pPM-C-His)

PV312101 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Mouse) (pPB-C-His)

PV240334 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Mouse) (pPB-N-His)

PV240335 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Mouse) (pPM-C-HA)

PV240336 500 ng
EUR 723.6

TNFRSF25 Protein Vector (Mouse) (pPM-C-His)

PV240337 500 ng
EUR 723.6

Tnfrsf25 3'UTR Luciferase Stable Cell Line

TU222242 1.0 ml Ask for price

Tnfrsf25 3'UTR GFP Stable Cell Line

TU170889 1.0 ml Ask for price

Tnfrsf25 3'UTR GFP Stable Cell Line

TU272242 1.0 ml Ask for price

Tnfrsf25 3'UTR Luciferase Stable Cell Line

TU120889 1.0 ml Ask for price

TNFRSF25 3'UTR GFP Stable Cell Line

TU076030 1.0 ml
EUR 1825.2

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