
Binding mechanisms of therapeutic antibodies to human CD20
Monoclonal antibodies (mAbs) focusing on human antigen CD20 (cluster of differentiation 20) represent vital immunotherapies for the therapy of B cell malignancies and autoimmune ailments. Sort I and II therapeutic mAbs differ in B cell binding properties and cytotoxic results, reflecting differential interplay mechanisms with CD20. Right here we current 3.7- to 4.7-angstrom cryo-electron microscopy constructions of full-length CD20 in complexes with prototypical sort I rituximab and ofatumumab and kind II obinutuzumab.
The constructions and binding thermodynamics show that upon binding to CD20, sort II mAbs type terminal complexes that preclude recruitment of further mAbs and complement parts, whereas sort I complexes act as molecular seeds to extend mAb native focus for environment friendly complement activation. Amongst sort I mAbs, ofatumumab complexes show optimum geometry for complement recruitment. The uncovered mechanisms ought to assist rational design of next-generation immunotherapies focusing on CD20.
Rational Design of a Sturdy Antibody-Like Small Molecule Inhibitor Nanoplatform for Enhanced Photoimmunotherapy
Immune checkpoint blockade of programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway through antibody is a potent technique for T cells transforming. Nonetheless, the efficiency of antibody is partly compromised by its excessive worth, instability, threat of autoimmune illness, and many others. Small molecule inhibitors are attention-grabbing alternate options to antibodies.
Nonetheless, tumor-specific supply of small molecule inhibitor to the goal web site for reinforcing the interruption of PD-L1/PD-1 pathway isn’t reported. Herein, we designed a tumor-specific supply nanoplatform that would effectively ship the small molecule inhibitor to the exact goal web site, significantly enhancing the blocking impact of PD-L1/PD-1 pathway. Hyaluronic acid (HA) was conjugated with chlorin e6 (Ce6), leading to a HA-Ce6 conjugate (HC).
The nanoplatform was constructed by the HC micelles with encapsulation of small molecule inhibitor BMS 202 (BMS) to type BMS/HC micelles. The goal property of HA, mixed with the hyaluronidase-induced degradation of HA in tumor web site, permits the as-prepared micelles with tumor-specific supply of BMS for blocking PD-L1/PD-1 pathway.
Cooperative therapy with the photosensitizer Ce6, the current therapeutic nanoplatform demonstrated glorious photoimmunotherapy for tumor regression in distant tumors and lung metastasis. This technique of tumor-specific supply of small molecule inhibitors gives an efficient pathway to strengthen the blocking efficacy of PD-L1/PD-1 on efficient photoimmunotherapy.

controlpeptidecomprimary-antibodies
Anti-human IL-4 antibody |
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STJ15100046 | St John's Laboratory | 250 µg | EUR 440.4 |
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot. |
anti- IL-4 antibody |
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FNab04278 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against IL-4 |
anti- IL-4 antibody |
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FNab04279 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against IL-4 |
anti- IL-4 antibody |
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LSMab09861 | Lifescience Market | 100 ug | EUR 463.2 |
anti- IL-4 antibody |
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FNab09861 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against IL-4 |
Anti-IL-4 antibody |
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PAab04278 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-IL-4 antibody |
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STJ96510 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4. |
Anti-IL-4 antibody |
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STJ93699 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4. |
Anti-IL-4 antibody |
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STJ93700 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4. |
Recombinant Human IL-17F Protein |
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PROTQ96PD4-4 | BosterBio | 25ug | EUR 380.4 |
Description: IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Recombinant human IL-17F is a disulfide-linked homodimer of 30.1 kDa, consisting of two 133 amino acid residue chains. |
Recombinant Human IL-6 Protein |
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PROTP05231-4 | BosterBio | 20ug | EUR 380.4 |
Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues. |
Recombinant Human IL-3 Protein |
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PROTP08700-4 | BosterBio | 10ug | EUR 380.4 |
Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues. |
Recombinant Human IL-2 Protein |
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PROTP60568-4 | BosterBio | 50ug | EUR 380.4 |
Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond. |
Rabbit Polyclonal antibody Anti-CRBN |
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Anti-CRBN | ImmunoStep | 50 µg | EUR 418.8 |
mAb mouse anti-human IL-4 |
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CT253 | U-CyTech | 0.5 mg | EUR 312 |
Recombinant Human IL-12 p80 Protein |
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PROTP29460-4 | BosterBio | 10ug | EUR 380.4 |
Description: IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12. |
Recombinant Human IL-13 Variant Protein |
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PROTP35225-4 | BosterBio | 10ug | EUR 380.4 |
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. PeproTech's genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112. |
Human Interleukin-4 (IL-4) |
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1-CSB-EP011659HU | Cusabio |
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Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli |
IL-4, Interleukin-4, human |
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RC212-15 | Bio Basic | 5ug | EUR 125.26 |
Anti-mouse IL-4 antibody |
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STJ15100035 | St John's Laboratory | 250 µg | EUR 403.2 |
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot. |
Anti-mouse IL-4 antibody |
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STJ15100036 | St John's Laboratory | 500 µg | EUR 632.4 |
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity. |
Anti-mouse IL-4 antibody |
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STJ15100037 | St John's Laboratory | 250 µg | EUR 440.4 |
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot. |
Anti-IL-4 alpha antibody |
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STJ97665 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4Ralpha. |
Anti-IL-4 alpha antibody |
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STJ93702 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4Ralpha. |
Anti-IL-4 alpha antibody |
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STJ93703 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4Ralpha. |
Recombinant Human IL-16 (129 a.a.) Protein |
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PROTQ14005-4 | BosterBio | 10ug | EUR 380.4 |
Description: IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.5 kDa protein consisting of 130 amino acid residues. |
IL-4 |
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E13-015-1 | EnoGene | 10μg | EUR 193.2 |
IL-4 |
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E13-015-2 | EnoGene | 50μg | EUR 606 |
IL-4 |
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MO15071 | Neuromics | 500 ug | EUR 1092 |
IL-4 |
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E21-050 | EnoGene | 10ug | EUR 411.6 |
IL-4 |
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E21-D03 | EnoGene | 10ug | EUR 411.6 |
IL-4 |
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E21-K15 | EnoGene | 10ug | EUR 411.6 |
pAb rabbit anti-human IL-4 receptor |
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CT248 | U-CyTech | 0.5 mg | EUR 220.8 |
Recombinant Human IL-8 (72 a.a.) (CXCL8) Protein |
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PROTP10145-4 | BosterBio | 25ug | EUR 380.4 |
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues. |
IL-4, human recombinant |
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4137-10 | Biovision | EUR 333.6 |
IL-4, human recombinant |
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4137-1000 | Biovision | EUR 4444.8 |
IL-4, human recombinant |
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4137-50 | Biovision | EUR 836.4 |
Human IL-4 Protein |
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abx060798-20ug | Abbexa | 20 ug | EUR 560.4 |
Recombinant Human IL-4 |
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P0052 | FN Test | 100ug | EUR 626.83 |
Description: Recombinant Human protein for IL-4 |
rec IL-4 (human) |
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H-9630.0002 | Bachem | 2.0µg | EUR 313.2 |
rec IL-4 (human) |
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H-9630.0010 | Bachem | 10.0µg | EUR 1140 |
Recombinant Human IL-4 |
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SJB02-03 | Amyotop | 10µg/vial | EUR 342 |
Recombinant Human IL-4 |
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SJB02-05 | Amyotop | 100µg/vial | EUR 864 |
Recombinant Human IL-4 |
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SJB02-06 | Amyotop | 30µg/vial | EUR 516 |
Interleukin-4/IL-4 |
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E21-K74 | EnoGene | 10ug | EUR 411.6 |
Swine IL-10 Recombinant Protein |
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R00021-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: IL-10 is an anti-inflammatory cytokine and a member of the IL-10 family of cytokines, which have indispensable functions in many infectious and inflammatory diseases. Swine IL-10 Recombinant Protein is purified interleukin-10 produced in yeast. |
Mouse IL-13 Recombinant Protein |
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R00077-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. Mouse IL-13 Recombinant Protein is purified interleukin-13 produced in yeast. |
Feline IL-6 Recombinant Protein |
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R00102-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Feline IL-6 Recombinant Protein is purified interleukin-6 produced in yeast. |
Feline IL-2 Recombinant Protein |
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R00387-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Feline IL-2 Recombinant Protein is purified interleukin-2 produced in yeast. |
Mouse IL-17A Recombinant Protein |
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R00421-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Mouse IL-17A Recombinant Protein is purified interleukin-17A produced in yeast. |
Dolphin IL-8 Recombinant Protein |
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R00423-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Dolphin IL-8 Recombinant Protein is purified interleukin-8 produced in yeast. |
Swine IL-21 Recombinant Protein |
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R00459-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: The cytokine interleukin-21 (IL-21) regulates the proliferation and differentiation of T and B lymphocytes, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. Swine IL-21 Recombinant Protein is purified interleukin-21 produced in yeast. |
Equine IL-1ra Recombinant Protein |
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R00651-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: Interleukin-1 Receptor Antagonist Protein (IL-1F3, IL-1ra) belongs to the IL-1 family of cytokines, whose members play key roles in the development and regulation of inflammation. IL-1 receptor antagonist (IL-1ra; IL-1F3) reduces inflammation by blocking the binding of the agonist receptor ligands. Equine IL-1 Receptor Antagonist Recombinant Protein is purified interleukin-1 receptor antagonist protein (IL-1F3, IL-1ra) produced in yeast. |
Human Interleukin-4 (IL-4) Antibody |
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32184-05111 | AssayPro | 150 ug | EUR 313.2 |
IL-7 Interleukin-7 Human Recombinant Protein, His Tag |
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PROTP13232-4 | BosterBio | Regular: 10ug | EUR 380.4 |
Description: IL-7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.97 kDa with an amino-terminal hexahistidine tag. ;The IL-7 His-Tag protein is purified by proprietary chromatographic techniques. |
mAb mouse anti-rat IL-4 |
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CT028 | U-CyTech | 0.5 mg | EUR 312 |
mAb mouse anti-rat IL-4 |
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CT029 | U-CyTech | 0.5 mg | EUR 312 |
pAb rabbit anti-rat IL-4 |
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CT058 | U-CyTech | 0.5 mg | EUR 220.8 |
mAb mouse anti-monkey IL-4 |
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CT103 | U-CyTech | 0.5 mg | EUR 312 |
mAb rat anti-mouse IL-4 |
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CT324 | U-CyTech | 0.5 mg | EUR 312 |
mAb rat anti-mouse IL-4 |
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CT337 | U-CyTech | 0.5 mg | EUR 312 |
Human FibrOut 4, for brain, neural |
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4-21552 | CHI Scientific | 1 ml | Ask for price |
Human FibrOut 4, for brain, neural |
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4-21553 | CHI Scientific | 5 x 1 ml | Ask for price |
Recombinant Human 4-1BB Receptor Protein |
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PROTQ07011-4 | BosterBio | 20ug | EUR 380.4 |
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor. |
Recombinant Human PF-4 (CXCL4) Protein |
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PROTP02776-4 | BosterBio | 20ug | EUR 380.4 |
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines. |
Feline IL-1 beta Recombinant Protein |
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R00101-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Feline IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast. |
Feline IL-1 alpha Recombinant Protein |
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R01144-4 | BosterBio | 5ug/vial | EUR 310.8 |
Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Feline IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast. |
rHu IL-4 |
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AK8329-0005 | Akron Biotech | 5µg | Ask for price |
rHu IL-4 |
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AK8329-0020 | Akron Biotech | 20µg | Ask for price |
rHu IL-4 |
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AK8329-0100 | Akron Biotech | 100µg | Ask for price |
rHu IL-4 |
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AK8329-1000 | Akron Biotech | 1mg | Ask for price |
IL-4 Antibody |
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5137-200 | Biovision | EUR 444 |
IL-4 Antibody |
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5137-30T | Biovision | EUR 175.2 |
IL-4 antigen |
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E6IE600107 | EnoGene | 20ug | EUR 411.6 |
IL-4 antigen |
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E6L00107 | EnoGene | 20ug | EUR 458.4 |
IL-4 antibody |
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PAab09861 | Lifescience Market | 100 ug | EUR 463.2 |
IL-4 Antibody |
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R30605 | NSJ Bioreagents | 100 ug | EUR 419 |
IL-4 Antibody |
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R30841 | NSJ Bioreagents | 100 ug | EUR 419 |
IL-4 Antibody |
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RQ4162 | NSJ Bioreagents | 100 ug | EUR 419 |
IL-4 Antibody |
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RQ5106 | NSJ Bioreagents | 100ul | EUR 419 |
IL-4 Antibody |
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V7884-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin. |
IL-4 Antibody |
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V7884-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin. |
IL-4 Antibody |
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V7884SAF-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin. |
IL-4 Antibody |
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V8351-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12. |
IL-4 Antibody |
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V8351-20UG | NSJ Bioreagents | 20 ug | EUR 219 |
Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12. |
IL-4 Antibody |
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V8351SAF-100UG | NSJ Bioreagents | 100 ug | EUR 499 |
Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12. |
IL-4 Antibody |
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F49086-0.08ML | NSJ Bioreagents | 0.08 ml | EUR 165 |
IL-4 Antibody |
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F49086-0.4ML | NSJ Bioreagents | 0.4 ml | EUR 379 |
Human Interleukin 4, IL-4 ELISA KIT |
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CSB-E04633h-24T | Cusabio | 1 plate of 24 wells | EUR 198 |
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Interleukin 4, IL-4 ELISA KIT |
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1-CSB-E04633h | Cusabio |
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Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Human Interleukin 4,IL-4 ELISA KIT |
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CN-03206H1 | ChemNorm | 96T | EUR 520.8 |
Human Interleukin 4,IL-4 ELISA KIT |
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CN-03206H2 | ChemNorm | 48T | EUR 340.8 |
Recombinant Human Interleukin-4 (rHu IL-4) |
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AK9839-0010 | Akron Biotech | 10ug | EUR 780 |
Recombinant Human Interleukin-4 (rHu IL-4) |
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AK9839-0030 | Akron Biotech | 30ug | EUR 1356 |
Recombinant Human Interleukin-4 (rHu IL-4) |
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AK9839-0100 | Akron Biotech | 100ug | EUR 2040 |
Preclinical Antitumor Exercise and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Affected person-Derived Xenografts
Guanylyl cyclase C (GCC) is a novel therapeutic goal with expression restricted to the apical facet of epithelial cell tight junctions regarded as solely accessible by intravenously administered brokers on malignant tissues the place GCC expression is aberrant.
- Within the current examine, we sought to judge the therapeutic potential of a second-generation investigational ADC, TAK-164, comprised of a human anti-GCC monoclonal antibody conjugated through a peptide linker to the extremely cytotoxic DNA alkylator, DGN549. The in vitro binding, payload launch, and in vitro exercise of TAK-164 was characterised motivating in vivo analysis.
- The efficacy of TAK-164 and the connection to publicity, pharmacodynamic marker activation, and biodistribution was evaluated in xenograft fashions and first human tumor xenograft (PHTX) fashions. We show TAK-164 selectively binds to, is internalized by, and has potent cytotoxic results towards GCC-expressing cells in vitro.
- A single intravenous administration of TAK-164 (0.76 mg/kg) resulted in vital progress charge inhibition in PHTX fashions of mCRC. Moreover, imaging research characterised TAK-164 uptake and exercise and confirmed constructive relationships between GCC expression and tumor uptake which correlated with antitumor exercise.
- Collectively, our information counsel that TAK-164 is very energetic in a number of GCC constructive tumors together with these refractory to TAK-264, a GCC-targeted auristatin ADC. A powerful relationship between uptake of 89Zr-labeled TAK-164, ranges of GCC expression and, most notably, response to TAK-164 remedy in GCC expressing xenografts and PHTX fashions.
- These information supported the scientific growth of TAK-164 as a part of a first-in-human scientific trial (NCT03449030).