Binding mechanisms of therapeutic antibodies to human CD20
Monoclonal antibodies (mAbs) focusing on human antigen CD20 (cluster of differentiation 20) represent vital immunotherapies for the therapy of B cell malignancies and autoimmune ailments. Sort I and II therapeutic mAbs differ in B cell binding properties and cytotoxic results, reflecting differential interplay mechanisms with CD20. Right here we current 3.7- to 4.7-angstrom cryo-electron microscopy constructions of full-length CD20 in complexes with prototypical sort I rituximab and ofatumumab and kind II obinutuzumab.
The constructions and binding thermodynamics show that upon binding to CD20, sort II mAbs type terminal complexes that preclude recruitment of further mAbs and complement parts, whereas sort I complexes act as molecular seeds to extend mAb native focus for environment friendly complement activation. Amongst sort I mAbs, ofatumumab complexes show optimum geometry for complement recruitment. The uncovered mechanisms ought to assist rational design of next-generation immunotherapies focusing on CD20.
Rational Design of a Sturdy Antibody-Like Small Molecule Inhibitor Nanoplatform for Enhanced Photoimmunotherapy
Immune checkpoint blockade of programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway through antibody is a potent technique for T cells transforming. Nonetheless, the efficiency of antibody is partly compromised by its excessive worth, instability, threat of autoimmune illness, and many others. Small molecule inhibitors are attention-grabbing alternate options to antibodies.
Nonetheless, tumor-specific supply of small molecule inhibitor to the goal web site for reinforcing the interruption of PD-L1/PD-1 pathway isn’t reported. Herein, we designed a tumor-specific supply nanoplatform that would effectively ship the small molecule inhibitor to the exact goal web site, significantly enhancing the blocking impact of PD-L1/PD-1 pathway. Hyaluronic acid (HA) was conjugated with chlorin e6 (Ce6), leading to a HA-Ce6 conjugate (HC).
The nanoplatform was constructed by the HC micelles with encapsulation of small molecule inhibitor BMS 202 (BMS) to type BMS/HC micelles. The goal property of HA, mixed with the hyaluronidase-induced degradation of HA in tumor web site, permits the as-prepared micelles with tumor-specific supply of BMS for blocking PD-L1/PD-1 pathway.
Cooperative therapy with the photosensitizer Ce6, the current therapeutic nanoplatform demonstrated glorious photoimmunotherapy for tumor regression in distant tumors and lung metastasis. This technique of tumor-specific supply of small molecule inhibitors gives an efficient pathway to strengthen the blocking efficacy of PD-L1/PD-1 on efficient photoimmunotherapy.
human anti-human IL-4 mAb (C1) |
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E4A09D04-C1 | EnoGene | 50ug | EUR 255 |
Description: Available in various conjugation types. |
Anti-Human IL-4 |
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GWB-BIG229 | GenWay Biotech | 500ug | Ask for price |
Anti-Human IL-4 Antibody |
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102-P34 | ReliaTech | 100 µg | EUR 245.7 |
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities. |
Anti-Human IL-4 Antibody |
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101-M05 | ReliaTech | 500 µg | EUR 246.75 |
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities. |
Anti-Human IL-4 Antibody |
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101-M508 | ReliaTech | 100 µg | EUR 399 |
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities. |
Anti-human IL-4 antibody |
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STJ15100045 | St John's Laboratory | 250 µg | EUR 403.2 |
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot. |
Anti-human IL-4 antibody |
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STJ15100046 | St John's Laboratory | 250 µg | EUR 440.4 |
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot. |
Anti‐Human IL‐17A |
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E2790213 | EnoGene | 100ul | EUR 225 |
Description: Available in various conjugation types. |
IL-4, Human |
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E34M006H | EnoGene | 5 μg | EUR 155 |
Human IL-4 |
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GWB-CB2917 | GenWay Biotech | 0.01 mg | Ask for price |
Human IL-4 |
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gAP-0227 | Angio Proteomie | 1mg | EUR 450 |
Human Interleukin-4 (IL-4) Antibody |
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32184-05111 | AssayPro | 150 ug | EUR 215 |
anti- IL-4 antibody |
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FNab09861 | FN Test | 100µg | EUR 658.5 |
Description: Antibody raised against IL-4 |
anti- IL-4 antibody |
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FNab04278 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against IL-4 |
anti- IL-4 antibody |
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FNab04279 | FN Test | 100µg | EUR 702 |
Description: Antibody raised against IL-4 |
anti- IL-4 antibody |
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LSMab09861 | Lifescience Market | 100 ug | EUR 463.2 |
Anti-IL-4 Antibody |
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ER1706-55 | HUABIO | 100ul | EUR 189 |
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNFβ and IFN-γ, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2, and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin. |
Anti-IL-4 Antibody |
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E38A8953 | EnoGene | 100ug/100ul | EUR 225 |
Description: Available in various conjugation types. |
Anti-IL-4 Antibody |
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E38A8961 | EnoGene | 100ug/100ul | EUR 225 |
Description: Available in various conjugation types. |
Anti-IL-4 antibody |
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PAab04278 | Lifescience Market | 100 ug | EUR 494.4 |
Anti-IL-4 antibody |
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STJ96510 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4. |
Anti-IL-4 antibody |
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STJ93699 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4. |
Anti-IL-4 antibody |
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STJ93700 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4. |
PE Anti-Human IL-4 Antibody |
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DL22181F-20Tests | DL Develop | 20Tests | EUR 222.5 |
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. |
PE Anti-Human IL-4 Antibody |
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DL22181F-50Tests | DL Develop | 50Tests | EUR 320 |
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. |
APC Anti-Human IL-4 Antibody |
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DL22182F-20Tests | DL Develop | 20Tests | EUR 245 |
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. |
APC Anti-Human IL-4 Antibody |
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DL22182F-50Tests | DL Develop | 50Tests | EUR 357.5 |
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. |
Rat Anti-Human IL-4, Antibody |
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GWB-ACBDBA | GenWay Biotech | 0.5 mg | Ask for price |
Rat Anti-Human IL-4, Antibody |
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GWB-600465 | GenWay Biotech | 0.5 mg | Ask for price |
Rat Anti-Human IL-4, Antibody |
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GWB-C54D97 | GenWay Biotech | 0.5 mg | Ask for price |
FITC Anti-Human IL-4 Antibody |
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DL22180F-20Tests | DL Develop | 20Tests | EUR 222.5 |
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. |
FITC Anti-Human IL-4 Antibody |
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DL22180F-50Tests | DL Develop | 50Tests | EUR 320 |
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. |
Purified Anti-Human IL-4 Antibody |
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DL22179F-100ug | DL Develop | 100μg | EUR 290 |
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. |
Purified Anti-Human IL-4 Antibody |
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DL22179F-25ug | DL Develop | 25μg | EUR 177.5 |
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells. |
mAb mouse anti-human IL-4 |
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CT253 | U-CyTech | 0.5 mg | EUR 312 |
mouse anti-human IL-4 mAb |
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E409C13-m100 | EnoGene | 100μL | EUR 395 |
Description: Available in various conjugation types. |
Rabbit anti-Human IL-4(CAP) |
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RM17744 | Abclonal | 1000μg | Ask for price |
Rabbit anti-Human IL-4(DET) |
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RM17745 | Abclonal | 100μg | Ask for price |
Mouse Monoclonal anti-human IL-4 |
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hAP-0404 | Angio Proteomie | 100ug | EUR 250 |
Sheep Polyclonal anti-human IL-4 |
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hAP-5265 | Angio Proteomie | 50ug | EUR 400 |
human anti-human IL-5 mAb |
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E4A09D05 | EnoGene | 50ug | EUR 255 |
Description: Available in various conjugation types. |
human anti-human IL-2 mAb |
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E409C12-h100 | EnoGene | 100μL | EUR 395 |
Description: Available in various conjugation types. |
human anti-human IL-5 mAb |
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E409C14-h100 | EnoGene | 100μL | EUR 395 |
Description: Available in various conjugation types. |
human anti-human IL-8 mAb |
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E409C16-h100 | EnoGene | 100μL | EUR 395 |
Description: Available in various conjugation types. |
human anti-human IL-1β mAb |
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E409C11-h100 | EnoGene | 100μL | EUR 395 |
Description: Available in various conjugation types. |
human anti-human IL-10 mAb |
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E409C17-h100 | EnoGene | 100μL | EUR 395 |
Description: Available in various conjugation types. |
Interleukin-4 (IL-4) Human |
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GWB-2A39E4 | GenWay Biotech | 0.01 mg | Ask for price |
Human Interleukin-4 (IL-4) |
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1-CSB-EP011659HU | Cusabio |
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Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli |
IL-4, Interleukin-4, human |
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RC212-15 | Bio Basic | 5ug | EUR 125.26 |
human anti-human IL-12/IL-23 p40 mAb(3H2) |
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E4A09D33-3H2 | EnoGene | 50ug | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human IL-12/IL-23 p40 mAb(5N9) |
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E4A09D33-5N9 | EnoGene | 50ug | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
human anti-human IL-12/IL-23 p40 mAb(1G11) |
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E4A09D33-1G11 | EnoGene | 50ug | EUR 275 |
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody |
rec IL-4 (human) |
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H-9630.0002 | Bachem | 2.0µg | EUR 313.2 |
rec IL-4 (human) |
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H-9630.0010 | Bachem | 10.0µg | EUR 1140 |
Anti-Interleukin-4 (IL-4) Antibody |
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Y108183 | ABM | 50 μg | EUR 455 |
Human IL-4 Protein |
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abx060798-20ug | Abbexa | 20 ug | EUR 560.4 |
Human IL-4 protein |
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PRP100273-100ug | Abbkine | 100 μg | EUR 1029 |
Description: Human IL-4 protein, expressed in E. coli |
Human IL-4 protein |
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PRP100273-1mg | Abbkine | 1 mg | EUR 7139 |
Description: Human IL-4 protein, expressed in E. coli |
Human IL-4 protein |
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PRP100273-20ug | Abbkine | 20 μg | EUR 509 |
Description: Human IL-4 protein, expressed in E. coli |
Human IL-4 protein |
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PRP2017-100ug | Abbkine | 100 μg | EUR 429 |
Description: Human IL-4 protein, expressed in HEK293 Cells |
Human IL-4 protein |
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PRP2017-10ug | Abbkine | 10 μg | EUR 59 |
Description: Human IL-4 protein, expressed in HEK293 Cells |
Human IL-4 protein |
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PRP2017-1mg | Abbkine | 1 mg | EUR 3739 |
Description: Human IL-4 protein, expressed in HEK293 Cells |
Human IL-4 protein |
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PRP2017-50ug | Abbkine | 50 μg | EUR 249 |
Description: Human IL-4 protein, expressed in HEK293 Cells |
Recombinant Human IL-4 |
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6486 | Immunochemistry | 5 µg | EUR 194 |
IL-4, human recombinant |
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4137-10 | Biovision | each | EUR 333.6 |
IL-4, human recombinant |
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4137-1000 | Biovision | each | EUR 4444.8 |
IL-4, human recombinant |
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4137-50 | Biovision | each | EUR 836.4 |
Recombinant Human IL-4 |
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HEILP-0401 | Cyagen | 5ug | Ask for price |
Recombinant Human IL-4 |
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P0052 | FN Test | 100ug | EUR 626.83 |
Description: Recombinant Human protein for IL-4 |
Recombinant Human IL-4 |
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SJB02-03 | Amyotop | 10µg/vial | EUR 342 |
Recombinant Human IL-4 |
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SJB02-05 | Amyotop | 100µg/vial | EUR 864 |
Recombinant Human IL-4 |
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SJB02-06 | Amyotop | 30µg/vial | EUR 516 |
Recombinant human IL-4 |
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rcyec-hil4 | InvivoGen FR | 10 µg | EUR 156.45 |
human IL-10 / IL-4 (without plate) |
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M874022001 | Tecan Benelux | 1 unit | EUR 244.37 |
human IL-10 / IL-4 (without plate) |
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M874030001 | Tecan Benelux | 1 unit | EUR 266.67 |
Human IL-4 Antibody Pair Set |
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ABPR-ZB073 | Creative Diagnostics | 5 plates, 15 plates | Ask for price |
Description: Quantitative determination of Human IL-4 |
Human IL-4 ELISA antibody pair |
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CT742-10 | U-CyTech | 10-plate | EUR 656.4 |
Human IL-4 ELISA antibody pair |
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CT742-20 | U-CyTech | 20-plate | EUR 1118.4 |
Polyclonal Anti- human IL-3 Antibody |
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GWB-BBP009 | GenWay Biotech | 0.1 mg | Ask for price |
Polyclonal Anti- human IL-6 Antibody |
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GWB-BBP013 | GenWay Biotech | 0.1 mg | Ask for price |
Polyclonal Anti- human IL-7 Antibody |
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GWB-BBP014 | GenWay Biotech | 0.1 mg | Ask for price |
Anti-Rat IL-4 Antibody |
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104-P05 | ReliaTech | 100 µg | EUR 245.7 |
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities. |
Rat anti-IL-4 Antibody |
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DL99451A-100ul | DL Develop | 100 ul | EUR 299 |
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra |
Rat anti-IL-4 Antibody |
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DL99451A-50ul | DL Develop | 50 ul | EUR 210 |
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra |
Rat anti-IL-4 Antibody |
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DL99459A-100ul | DL Develop | 100 ul | EUR 299 |
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra |
Rat anti-IL-4 Antibody |
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DL99459A-50ul | DL Develop | 50 ul | EUR 210 |
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra |
Anti-IL-4 Antibody [A7D7] |
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HA601034 | HUABIO | 100ul | EUR 210 |
Description: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. |
Polyclonal Anti- human IL-10 Antibody |
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GWB-BBP015 | GenWay Biotech | 0.1 mg | Ask for price |
Anti-Mouse IL-4 Antibody |
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103-M422 | ReliaTech | 100 µg | EUR 399 |
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities. |
Anti-Mouse IL-4 Antibody |
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103-P14 | ReliaTech | 100 µg | EUR 245.7 |
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities. |
Anti-mouse IL-4 antibody |
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STJ15100035 | St John's Laboratory | 250 µg | EUR 403.2 |
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot. |
Anti-mouse IL-4 antibody |
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STJ15100036 | St John's Laboratory | 500 µg | EUR 632.4 |
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity. |
Anti-mouse IL-4 antibody |
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STJ15100037 | St John's Laboratory | 250 µg | EUR 440.4 |
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot. |
Anti-IL-4 alpha antibody |
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STJ97665 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4Ralpha. |
Anti-IL-4 alpha antibody |
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STJ93702 | St John's Laboratory | 200 µl | EUR 236.4 |
Description: Rabbit polyclonal to IL-4Ralpha. |
Preclinical Antitumor Exercise and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Affected person-Derived Xenografts
Guanylyl cyclase C (GCC) is a novel therapeutic goal with expression restricted to the apical facet of epithelial cell tight junctions regarded as solely accessible by intravenously administered brokers on malignant tissues the place GCC expression is aberrant.
- Within the current examine, we sought to judge the therapeutic potential of a second-generation investigational ADC, TAK-164, comprised of a human anti-GCC monoclonal antibody conjugated through a peptide linker to the extremely cytotoxic DNA alkylator, DGN549. The in vitro binding, payload launch, and in vitro exercise of TAK-164 was characterised motivating in vivo analysis.
- The efficacy of TAK-164 and the connection to publicity, pharmacodynamic marker activation, and biodistribution was evaluated in xenograft fashions and first human tumor xenograft (PHTX) fashions. We show TAK-164 selectively binds to, is internalized by, and has potent cytotoxic results towards GCC-expressing cells in vitro.
- A single intravenous administration of TAK-164 (0.76 mg/kg) resulted in vital progress charge inhibition in PHTX fashions of mCRC. Moreover, imaging research characterised TAK-164 uptake and exercise and confirmed constructive relationships between GCC expression and tumor uptake which correlated with antitumor exercise.
- Collectively, our information counsel that TAK-164 is very energetic in a number of GCC constructive tumors together with these refractory to TAK-264, a GCC-targeted auristatin ADC. A powerful relationship between uptake of 89Zr-labeled TAK-164, ranges of GCC expression and, most notably, response to TAK-164 remedy in GCC expressing xenografts and PHTX fashions.
- These information supported the scientific growth of TAK-164 as a part of a first-in-human scientific trial (NCT03449030).