Binding mechanisms of therapeutic antibodies to human CD20

controlpeptidecomprimary-antibodies

Binding mechanisms of therapeutic antibodies to human CD20

 

Monoclonal antibodies (mAbs) focusing on human antigen CD20 (cluster of differentiation 20) represent vital immunotherapies for the therapy of B cell malignancies and autoimmune ailments. Sort I and II therapeutic mAbs differ in B cell binding properties and cytotoxic results, reflecting differential interplay mechanisms with CD20. Right here we current 3.7- to 4.7-angstrom cryo-electron microscopy constructions of full-length CD20 in complexes with prototypical sort I rituximab and ofatumumab and kind II obinutuzumab.
The constructions and binding thermodynamics show that upon binding to CD20, sort II mAbs type terminal complexes that preclude recruitment of further mAbs and complement parts, whereas sort I complexes act as molecular seeds to extend mAb native focus for environment friendly complement activation. Amongst sort I mAbs, ofatumumab complexes show optimum geometry for complement recruitment. The uncovered mechanisms ought to assist rational design of next-generation immunotherapies focusing on CD20.

Rational Design of a Sturdy Antibody-Like Small Molecule Inhibitor Nanoplatform for Enhanced Photoimmunotherapy

Immune checkpoint blockade of programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway through antibody is a potent technique for T cells transforming. Nonetheless, the efficiency of antibody is partly compromised by its excessive worth, instability, threat of autoimmune illness, and many others. Small molecule inhibitors are attention-grabbing alternate options to antibodies.
Nonetheless, tumor-specific supply of small molecule inhibitor to the goal web site for reinforcing the interruption of PD-L1/PD-1 pathway isn’t reported. Herein, we designed a tumor-specific supply nanoplatform that would effectively ship the small molecule inhibitor to the exact goal web site, significantly enhancing the blocking impact of PD-L1/PD-1 pathway. Hyaluronic acid (HA) was conjugated with chlorin e6 (Ce6), leading to a HA-Ce6 conjugate (HC).
The nanoplatform was constructed by the HC micelles with encapsulation of small molecule inhibitor BMS 202 (BMS) to type BMS/HC micelles. The goal property of HA, mixed with the hyaluronidase-induced degradation of HA in tumor web site, permits the as-prepared micelles with tumor-specific supply of BMS for blocking PD-L1/PD-1 pathway.
Cooperative therapy with the photosensitizer Ce6, the current therapeutic nanoplatform demonstrated glorious photoimmunotherapy for tumor regression in distant tumors and lung metastasis. This technique of tumor-specific supply of small molecule inhibitors gives an efficient pathway to strengthen the blocking efficacy of PD-L1/PD-1 on efficient photoimmunotherapy.
controlpeptidecomprimary-antibodies

controlpeptidecomprimary-antibodies

human anti-human IL-4 mAb (C1)

E4A09D04-C1 50ug
EUR 255
Description: Available in various conjugation types.

Anti-Human IL-4

GWB-BIG229 500ug Ask for price

Anti-Human IL-4 Antibody

102-P34 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody

101-M05 500 µg
EUR 246.75
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody

101-M508 100 µg
EUR 399
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-human IL-4 antibody

STJ15100045 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Anti-human IL-4 antibody

STJ15100046 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Anti‐Human IL‐17A

E2790213 100ul
EUR 225
Description: Available in various conjugation types.

IL-4, Human

E34M006H 5 μg
EUR 155

Human IL-4

GWB-CB2917 0.01 mg Ask for price

Human IL-4

gAP-0227 1mg
EUR 450

Human Interleukin-4 (IL-4) Antibody

32184-05111 150 ug
EUR 215

anti- IL-4 antibody

FNab09861 100µg
EUR 658.5
Description: Antibody raised against IL-4

anti- IL-4 antibody

FNab04278 100µg
EUR 702
Description: Antibody raised against IL-4

anti- IL-4 antibody

FNab04279 100µg
EUR 702
Description: Antibody raised against IL-4

anti- IL-4 antibody

LSMab09861 100 ug
EUR 463.2

Anti-IL-4 Antibody

ER1706-55 100ul
EUR 189
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNFβ and IFN-γ, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2, and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

Anti-IL-4 Antibody

E38A8953 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Anti-IL-4 Antibody

E38A8961 100ug/100ul
EUR 225
Description: Available in various conjugation types.

Anti-IL-4 antibody

PAab04278 100 ug
EUR 494.4

Anti-IL-4 antibody

STJ96510 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody

STJ93699 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody

STJ93700 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

PE Anti-Human IL-4 Antibody

DL22181F-20Tests 20Tests
EUR 222.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody

DL22181F-50Tests 50Tests
EUR 320
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody

DL22182F-20Tests 20Tests
EUR 245
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody

DL22182F-50Tests 50Tests
EUR 357.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Rat Anti-Human IL-4, Antibody

GWB-ACBDBA 0.5 mg Ask for price

Rat Anti-Human IL-4, Antibody

GWB-600465 0.5 mg Ask for price

Rat Anti-Human IL-4, Antibody

GWB-C54D97 0.5 mg Ask for price

FITC Anti-Human IL-4 Antibody

DL22180F-20Tests 20Tests
EUR 222.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

FITC Anti-Human IL-4 Antibody

DL22180F-50Tests 50Tests
EUR 320
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Purified Anti-Human IL-4 Antibody

DL22179F-100ug 100μg
EUR 290
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Purified Anti-Human IL-4 Antibody

DL22179F-25ug 25μg
EUR 177.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

mAb mouse anti-human IL-4

CT253 0.5 mg
EUR 312

mouse anti-human IL-4 mAb

E409C13-m100 100μL
EUR 395
Description: Available in various conjugation types.

Rabbit anti-Human IL-4(CAP)

RM17744 1000μg Ask for price

Rabbit anti-Human IL-4(DET)

RM17745 100μg Ask for price

Mouse Monoclonal anti-human IL-4

hAP-0404 100ug
EUR 250

Sheep Polyclonal anti-human IL-4

hAP-5265 50ug
EUR 400

human anti-human IL-5 mAb

E4A09D05 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-2 mAb

E409C12-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb

E409C14-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb

E409C16-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-1β mAb

E409C11-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb

E409C17-h100 100μL
EUR 395
Description: Available in various conjugation types.

Interleukin-4 (IL-4) Human

GWB-2A39E4 0.01 mg Ask for price

Human Interleukin-4 (IL-4)

1-CSB-EP011659HU
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli

IL-4, Interleukin-4, human

RC212-15 5ug
EUR 125.26

human anti-human IL-12/IL-23 p40 mAb(3H2)

E4A09D33-3H2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)

E4A09D33-5N9 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(1G11)

E4A09D33-1G11 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

rec IL-4 (human)

H-9630.0002 2.0µg
EUR 313.2

rec IL-4 (human)

H-9630.0010 10.0µg
EUR 1140

Anti-Interleukin-4 (IL-4) Antibody

Y108183 50 μg
EUR 455

Human IL-4 Protein

abx060798-20ug 20 ug
EUR 560.4

Human IL-4 protein

PRP100273-100ug 100 μg
EUR 1029
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein

PRP100273-1mg 1 mg
EUR 7139
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein

PRP100273-20ug 20 μg
EUR 509
Description: Human IL-4 protein, expressed in E. coli

Human IL-4 protein

PRP2017-100ug 100 μg
EUR 429
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein

PRP2017-10ug 10 μg
EUR 59
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein

PRP2017-1mg 1 mg
EUR 3739
Description: Human IL-4 protein, expressed in HEK293 Cells

Human IL-4 protein

PRP2017-50ug 50 μg
EUR 249
Description: Human IL-4 protein, expressed in HEK293 Cells

Recombinant Human IL-4

6486 5 µg
EUR 194

IL-4, human recombinant

4137-10 each
EUR 333.6

IL-4, human recombinant

4137-1000 each
EUR 4444.8

IL-4, human recombinant

4137-50 each
EUR 836.4

Recombinant Human IL-4

HEILP-0401 5ug Ask for price

Recombinant Human IL-4

P0052 100ug
EUR 626.83
Description: Recombinant Human protein for IL-4

Recombinant Human IL-4

SJB02-03 10µg/vial
EUR 342

Recombinant Human IL-4

SJB02-05 100µg/vial
EUR 864

Recombinant Human IL-4

SJB02-06 30µg/vial
EUR 516

Recombinant human IL-4

rcyec-hil4 10 µg
EUR 156.45

human IL-10 / IL-4 (without plate)

M874022001 1 unit
EUR 244.37

human IL-10 / IL-4 (without plate)

M874030001 1 unit
EUR 266.67

Human IL-4 Antibody Pair Set

ABPR-ZB073 5 plates, 15 plates Ask for price
Description: Quantitative determination of Human IL-4

Human IL-4 ELISA antibody pair

CT742-10 10-plate
EUR 656.4

Human IL-4 ELISA antibody pair

CT742-20 20-plate
EUR 1118.4

Polyclonal Anti- human IL-3 Antibody

GWB-BBP009 0.1 mg Ask for price

Polyclonal Anti- human IL-6 Antibody

GWB-BBP013 0.1 mg Ask for price

Polyclonal Anti- human IL-7 Antibody

GWB-BBP014 0.1 mg Ask for price

Anti-Rat IL-4 Antibody

104-P05 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Rat anti-IL-4 Antibody

DL99451A-100ul 100 ul
EUR 299
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Rat anti-IL-4 Antibody

DL99451A-50ul 50 ul
EUR 210
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Rat anti-IL-4 Antibody

DL99459A-100ul 100 ul
EUR 299
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Rat anti-IL-4 Antibody

DL99459A-50ul 50 ul
EUR 210
Description: Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra

Anti-IL-4 Antibody [A7D7]

HA601034 100ul
EUR 210
Description: The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Polyclonal Anti- human IL-10 Antibody

GWB-BBP015 0.1 mg Ask for price

Anti-Mouse IL-4 Antibody

103-M422 100 µg
EUR 399
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Mouse IL-4 Antibody

103-P14 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-mouse IL-4 antibody

STJ15100035 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-mouse IL-4 antibody

STJ15100036 500 µg
EUR 632.4
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity.

Anti-mouse IL-4 antibody

STJ15100037 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-IL-4 alpha antibody

STJ97665 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Anti-IL-4 alpha antibody

STJ93702 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Preclinical Antitumor Exercise and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Affected person-Derived Xenografts

Guanylyl cyclase C (GCC) is a novel therapeutic goal with expression restricted to the apical facet of epithelial cell tight junctions regarded as solely accessible by intravenously administered brokers on malignant tissues the place GCC expression is aberrant.
  • Within the current examine, we sought to judge the therapeutic potential of a second-generation investigational ADC, TAK-164, comprised of a human anti-GCC monoclonal antibody conjugated through a peptide linker to the extremely cytotoxic DNA alkylator, DGN549. The in vitro binding, payload launch, and in vitro exercise of TAK-164 was characterised motivating in vivo analysis.
  • The efficacy of TAK-164 and the connection to publicity, pharmacodynamic marker activation, and biodistribution was evaluated in xenograft fashions and first human tumor xenograft (PHTX) fashions. We show TAK-164 selectively binds to, is internalized by, and has potent cytotoxic results towards GCC-expressing cells in vitro.
  • A single intravenous administration of TAK-164 (0.76 mg/kg) resulted in vital progress charge inhibition in PHTX fashions of mCRC. Moreover, imaging research characterised TAK-164 uptake and exercise and confirmed constructive relationships between GCC expression and tumor uptake which correlated with antitumor exercise.
  • Collectively, our information counsel that TAK-164 is very energetic in a number of GCC constructive tumors together with these refractory to TAK-264, a GCC-targeted auristatin ADC. A powerful relationship between uptake of 89Zr-labeled TAK-164, ranges of GCC expression and, most notably, response to TAK-164 remedy in GCC expressing xenografts and PHTX fashions.
  • These information supported the scientific growth of TAK-164 as a part of a first-in-human scientific trial (NCT03449030).

CXCL14/BRAK, human recombinant

4278-10 each
EUR 288

CXCL14/BRAK, human recombinant

4278-1000 each
EUR 3348

CXCL14/BRAK, human recombinant

4278-50 each
EUR 705.6

Recombinant Human CXCL14 (BRAK)

Z102375 20 µg
EUR 195
Description: Chemokine (CXC motif) ligand 14, also known as breast and kidney-expressed chemokine (BRAK), is a CXC chemokine that is a potent chemoattractant for neutrophils but not for T-cells, B-cells, monocytes or granulocytes. Mature CXCL14 has many conserved features of the CXC family and is 30% homologous to the MIP-α and MIP-β sequences, but differs in that it has an additional five amino acid sequence in between the third and fourth cysteines and a short N-terminus. It is usually highly expressed near its fibroblast source and in epidermal fibroblasts and keratinocytes of skin, but is absent from cancer cells.

Recombinant Human CXCL14 (BRAK)

Z102379 1.0 mg
EUR 3900
Description: Chemokine (CXC motif) ligand 14, also known as breast and kidney-expressed chemokine (BRAK), is a CXC chemokine that is a potent chemoattractant for neutrophils but not for T-cells, B-cells, monocytes or granulocytes. Mature CXCL14 has many conserved features of the CXC family and is 30% homologous to the MIP-α and MIP-β sequences, but differs in that it has an additional five amino acid sequence in between the third and fourth cysteines and a short N-terminus. It is usually highly expressed near its fibroblast source and in epidermal fibroblasts and keratinocytes of skin, but is absent from cancer cells.

BRAK (CXCL14) Human Recombinant

rAP-0116 Inquiry Ask for price

Mouse Monoclonal anti-human CXCL14 (BRAK)

hAP-0213 100ug
EUR 250

Sheep Polyclonal anti-Human CXCL14 (BRAK)

hAP-5820 50ug
EUR 400

Anti-Human BRAK Rabbit Polyclonal Antibody

TA328274 100 µg Ask for price

BRAK

chm-001 5µg
EUR 60
Description: Recombinant Human BRAK (CXCL14)

BRAK antibody

70R-BR016 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal BRAK antibody

Human CXCL14/BRAK ELISA Kit

E16HE0215 96T
EUR 833.33

Human BRAK (CXCL14) Recombinant Protein

100-139 20 µg
EUR 196.35
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Human BRAK (CXCL14) Recombinant Protein

100-139S 5 µg
EUR 92.4
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Recombinant Human BRAK (CXCL14) Protein

PROTO95715-2 20ug
EUR 380.4
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 α and β. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Recombinant Human CXCL14/BRAK Protein

E40KMP1499 20ug
EUR 495

BRAK (CXCL14) Human Recombinant Protein

PROTO95715 Regular: 20ug
EUR 380.4
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.;The CXCL14 is purified by proprietary chromatographic techniques.

Recombinant Human CXCL14/BRAK Protein

RP00348 10 μg
EUR 1137.5

Human BRAK Recombinant Protein Lyophilized

IHUBRAKRLY5UG each
EUR 341
Description: Human BRAK Recombinant Protein Lyophilized

Biotinylated Anti-Human BRAK Rabbit Polyclonal Antibody

TA328273 50 µg Ask for price

BRAK His

chm-239 1µg
EUR 60
Description: Recombinant Human BRAK (CXCL14), His Tag

Recombinant Human BRAK (CXCL14), His Tag

7-01780 5µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag

7-01781 20µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag

7-01782 1mg Ask for price

BRAK protein

30R-AB037 20 ug
EUR 312
Description: Human recombinant BRAK protein

BRAK Human Recombinant (CXCL14), His-Tag

rAP-0119 Inquiry Ask for price

Nori® Human CXCL14/BRAK ELISA Kit

GR106314 96-well
EUR 461

Human BRAK Flow Cytometry Assay - Group 6

HX87213 96 Tests
EUR 270

Recombinant Human BRAK Protein, His, E.coli-1ug

QP11201-1ug 1ug
EUR 186

Recombinant Human BRAK Protein, His, E.coli-5ug

QP11201-5ug 5ug
EUR 241.2

Recombinant Human BRAK Protein, His, E.coli-50ug

QP11201-50ug 50ug
EUR 1513.2

Human, BRAK Human Recombinant Protein (CXCL14), His-Tag

PROTO95715-1 Regular: 5ug
EUR 380.4
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.66 kDa. ;The Human BRAK contains a 10 a.a. fusion His tag at N-Terminus. ;The BRAK is purified by proprietary chromatographic techniques.

Recombinant Human BRAK Protein, Untagged, E.coli-1mg

QP10538-1mg 1mg
EUR 3308.4

Recombinant Human BRAK Protein, Untagged, E.coli-5ug

QP10538-5ug 5ug
EUR 186

Recombinant Human BRAK Protein, Untagged, E.coli-20ug

QP10538-20ug 20ug
EUR 241.2

BRAK Recombinant Protein

40-401-0005mg 0.005 mg
EUR 311.1
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

BRAK Recombinant Protein

40-401-002mg 0.02 mg
EUR 437.1
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Rat BRAK ELISA Kit

ERB0616 96Tests
EUR 625.2

Goat BRAK ELISA Kit

EGTB0616 96Tests
EUR 625.2

Sheep BRAK ELISA Kit

ESB0616 96Tests
EUR 625.2

Mouse BRAK ELISA Kit

EMB0616 96Tests
EUR 625.2

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human)

4-PAB607Hu01
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK)

Bovine BRAK ELISA Kit

EBB0616 96Tests
EUR 625.2

Canine BRAK ELISA Kit

ECB0616 96Tests
EUR 625.2

Monkey BRAK ELISA Kit

EMKB0616 96Tests
EUR 625.2

Rabbit BRAK ELISA Kit

ERTB0616 96Tests
EUR 625.2

Chicken BRAK ELISA Kit

ECKB0616 96Tests
EUR 625.2

Porcine BRAK ELISA Kit

EPB0616 96Tests
EUR 625.2

Human Breast And Kidney Expressed Chemokine (BRAK) Protein

20-abx168163
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Anserine BRAK ELISA Kit

EAB0616 96Tests
EUR 625.2

BRAK, CXCL14, murine (mouse)

RC332-25 5ug
EUR 125.26

Human BRAK(Breast And Kidney Expressed Chemokine) ELISA Kit

ELK2082-48T 48T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BRAK. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human BRAK. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human BRAK, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BRAK in the samples is then determined by comparing the OD of the samples to the standard curve.

Human BRAK(Breast And Kidney Expressed Chemokine) ELISA Kit

ELK2082-96T 96T Ask for price
Description: The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human BRAK. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human BRAK. Next, Avidin conjugated to Horseradish Peroxidase (HRP) is added to each microplate well and incubated. After TMB substrate solution is added, only those wells that contain Human BRAK, biotin-conjugated antibody and enzyme-conjugated Avidin will exhibit a change in color. The enzyme-substrate reaction is terminated by the addition of sulphuric acid solution and the color change is measured spectrophotometrically at a wavelength of 450nm ± 10nm. The concentration of Human BRAK in the samples is then determined by comparing the OD of the samples to the standard curve.

Recombinant Rat BRAK/CXCL14

RECXP-1401 5ug Ask for price

BRAK (CXCL14) Rat Recombinant

rAP-0118 Inquiry Ask for price

OOPA00002-5UG - BRAK Protein

OOPA00002-5UG 5ug
EUR 70

OPPA01591-5UG - BRAK Protein

OPPA01591-5UG 5ug
EUR 154

BRAK (CXCL14) Mouse Recombinant

rAP-0117 Inquiry Ask for price

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), APC

4-PAB607Hu01-APC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with APC.

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), Cy3

4-PAB607Hu01-Cy3
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with Cy3.

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), HRP

4-PAB607Hu01-HRP
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with HRP.

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), PE

4-PAB607Hu01-PE
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with PE.

Recombinant Murine BRAK/CXCL14

MECXP-1401 5ug Ask for price

Human Breast And Kidney Expressed Chemokine (BRAK) CLIA Kit

20-abx190238
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit

SCB607Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit

SCB607Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit

SCB607Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit

SCB607Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) CLIA Kit

4-SCB607Hu
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK)Serum, plasma and other biological fluids

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human), FITC

4-PAB607Hu01-FITC
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • Ask for price
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK). This antibody is labeled with FITC.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

20-abx150834
  • Ask for price
  • Ask for price
  • Ask for price
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Breast and kidney expressed chemokine,BRAK ELISA Kit

201-12-0062 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

DLR-BRAK-Hu 96T
EUR 443
Description: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

DLR-BRAK-Hu-48T 48T
EUR 597.6
Description: A sandwich quantitative ELISA assay kit for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

DLR-BRAK-Hu-96T 96T
EUR 776.4
Description: A sandwich quantitative ELISA assay kit for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

EKL55886-5x96T 5x96T
EUR 3622.83

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit

EKL55886-96T 96T
EUR 762.7

Human Breast and kidney expressed chemokine,BRAK ELISA Kit

EKC40727-48T 48T
EUR 597.24

Human Breast and kidney expressed chemokine,BRAK ELISA Kit

EKC40727-5x96T 5x96T
EUR 4052.7

Human Breast and kidney expressed chemokine,BRAK ELISA Kit

EKC40727-96T 96T
EUR 853.2

Human Breast and kidney expressed chemokine(BRAK) Elisa Kit

EK700372 96 Wells
EUR 0.35

Leave a Reply

Your email address will not be published. Required fields are marked *