Binding mechanisms of therapeutic antibodies to human CD20

controlpeptidecomprimary-antibodies

Binding mechanisms of therapeutic antibodies to human CD20

 

Monoclonal antibodies (mAbs) focusing on human antigen CD20 (cluster of differentiation 20) represent vital immunotherapies for the therapy of B cell malignancies and autoimmune ailments. Sort I and II therapeutic mAbs differ in B cell binding properties and cytotoxic results, reflecting differential interplay mechanisms with CD20. Right here we current 3.7- to 4.7-angstrom cryo-electron microscopy constructions of full-length CD20 in complexes with prototypical sort I rituximab and ofatumumab and kind II obinutuzumab.
The constructions and binding thermodynamics show that upon binding to CD20, sort II mAbs type terminal complexes that preclude recruitment of further mAbs and complement parts, whereas sort I complexes act as molecular seeds to extend mAb native focus for environment friendly complement activation. Amongst sort I mAbs, ofatumumab complexes show optimum geometry for complement recruitment. The uncovered mechanisms ought to assist rational design of next-generation immunotherapies focusing on CD20.

Rational Design of a Sturdy Antibody-Like Small Molecule Inhibitor Nanoplatform for Enhanced Photoimmunotherapy

Immune checkpoint blockade of programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway through antibody is a potent technique for T cells transforming. Nonetheless, the efficiency of antibody is partly compromised by its excessive worth, instability, threat of autoimmune illness, and many others. Small molecule inhibitors are attention-grabbing alternate options to antibodies.
Nonetheless, tumor-specific supply of small molecule inhibitor to the goal web site for reinforcing the interruption of PD-L1/PD-1 pathway isn’t reported. Herein, we designed a tumor-specific supply nanoplatform that would effectively ship the small molecule inhibitor to the exact goal web site, significantly enhancing the blocking impact of PD-L1/PD-1 pathway. Hyaluronic acid (HA) was conjugated with chlorin e6 (Ce6), leading to a HA-Ce6 conjugate (HC).
The nanoplatform was constructed by the HC micelles with encapsulation of small molecule inhibitor BMS 202 (BMS) to type BMS/HC micelles. The goal property of HA, mixed with the hyaluronidase-induced degradation of HA in tumor web site, permits the as-prepared micelles with tumor-specific supply of BMS for blocking PD-L1/PD-1 pathway.
Cooperative therapy with the photosensitizer Ce6, the current therapeutic nanoplatform demonstrated glorious photoimmunotherapy for tumor regression in distant tumors and lung metastasis. This technique of tumor-specific supply of small molecule inhibitors gives an efficient pathway to strengthen the blocking efficacy of PD-L1/PD-1 on efficient photoimmunotherapy.
controlpeptidecomprimary-antibodies

controlpeptidecomprimary-antibodies

Human anti-Human IL-4 mAb

MBS8576802-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-4 mAb

MBS8576802-01mLAF635 0.1mL(AF635)
EUR 565

Polyclonal Anti- human IL-4 Antibody

GWB-BBP010 0.1 mg Ask for price

human anti-human IL-4 mAb (12)

E4A09D04-12 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (52)

E4A09D04-52 50ug
EUR 255
Description: Available in various conjugation types.

human anti-human IL-4 mAb (C1)

E4A09D04-C1 50ug
EUR 255
Description: Available in various conjugation types.

Rat Anti Human Interleukin-4, IL-4, unconjugated

MBS396740-01mg 0.1mg
EUR 260

Rat Anti Human Interleukin-4, IL-4, unconjugated

MBS396740-5x01mg 5x0.1mg
EUR 1015

Rat Anti Human Interleukin-4, IL-4, unconjugated

MBS396742-01mg 0.1mg
EUR 260

Rat Anti Human Interleukin-4, IL-4, unconjugated

MBS396742-5x01mg 5x0.1mg
EUR 1015

Rat Anti Human Interleukin-4, IL-4, unconjugated

MBS396744-01mg 0.1mg
EUR 260

Rat Anti Human Interleukin-4, IL-4, unconjugated

MBS396744-5x01mg 5x0.1mg
EUR 1015

Anti-Human IL-4

GWB-BIG229 500ug Ask for price

Anti-Human IL-4

MBS550674-01mg 0.1mg
EUR 260

Anti-Human IL-4

MBS550674-02mg 0.2mg
EUR 335

Anti-Human IL-4

MBS550686-01mg 0.1mg
EUR 260

Anti-Human IL-4

MBS550686-02mg 0.2mg
EUR 335

Anti‐Human IL‐17A

E2790213 100ul
EUR 225
Description: Available in various conjugation types.

IL-4, Human

E34M006H 5 μg
EUR 155

Human IL-4

GWB-CB2917 0.01 mg Ask for price

Human IL-4

gAP-0227 1mg
EUR 450

Human IL-4

MBS691496-0002mg 0.002mg
EUR 225

Human IL-4

MBS691496-5x0002mg 5x0.002mg
EUR 725

Human IL-4

MBS691811-005mg 0.05mg
EUR 555

Human IL-4

MBS691811-5x005mg 5x0.05mg
EUR 2205

Human IL-4

MBS691915-001mg 0.01mg
EUR 265

Human IL-4

MBS691915-5x001mg 5x0.01mg
EUR 890

IL-4, Human

MBS8575163-0005mg 0.005mg
EUR 245

IL-4, Human

MBS8575163-5x0005mg 5x0.005mg
EUR 940

Anti-Human IL-4 Antibody

101-M05 500 µg
EUR 246.75
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody

101-M508 100 µg
EUR 399
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-Human IL-4 Antibody

102-P34 100 µg
EUR 245.7
Description: Interleukin 4 (IL-4) is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. It was initially identified as a B cell differentiation factor (BCDF), as well as a B cell stimulatory factor (BSF1). IL-4 has since been shown to have multiple biological effects on hematopoietic and non-hematopoietic cells, including B and T cells, monocytes, macrophages, mast cells, myeloid and erythroid progenitors, fibroblasts, and endothelial cells. Rat, mouse and human IL-4 are species-specific in their activities.

Anti-human IL-4 antibody

STJ15100045 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Anti-human IL-4 antibody

STJ15100046 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Human Interleukin-4 (IL-4) Antibody

32184-05111 150 ug
EUR 215

Anti-Human IL-4 PE

MBS697227-100Tests 100Tests
EUR 360

Anti-Human IL-4 PE

MBS697227-25Tests 25Tests
EUR 215

Anti-Human IL-4 PE

MBS697227-5x100Tests 5x100Tests
EUR 1580

Anti-Human IL-4 PE

MBS697234-100Tests 100Tests
EUR 335

Anti-Human IL-4 PE

MBS697234-25Tests 25Tests
EUR 185

Anti-Human IL-4 PE

MBS697234-5x100Tests 5x100Tests
EUR 1475

Anti-Human IL-4 APC

MBS697235-100Tests 100Tests
EUR 320

Anti-Human IL-4 APC

MBS697235-25Tests 25Tests
EUR 185

Anti-Human IL-4 APC

MBS697235-5x100Tests 5x100Tests
EUR 1395

Mouse Anti-Human IL-4

MBS690917-05mg 0.5mg
EUR 525

Mouse Anti-Human IL-4

MBS690917-5x05mg 5x0.5mg
EUR 2080

Human Interleukin-4 (IL-4)

1-CSB-EP011659HU
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  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli

Interleukin-4 (IL-4) Human

GWB-2A39E4 0.01 mg Ask for price

IL-4, Interleukin-4, human

RC212-15 5ug
EUR 125.26

human anti-human IL-2 mAb

E409C12-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb

E409C14-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-8 mAb

E409C16-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-5 mAb

E4A09D05 50ug
EUR 255
Description: Available in various conjugation types.

Human anti-Human IL-2 mAb

MBS8576800-005mg 0.05mg
EUR 325

Human anti-Human IL-2 mAb

MBS8576800-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-2 mAb

MBS8576800-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-2 mAb

MBS8576800-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-2 mAb

MBS8576800-01mLAF635 0.1mL(AF635)
EUR 565

Human anti-Human IL-5 mAb

MBS8576804-005mg 0.05mg
EUR 325

Human anti-Human IL-5 mAb

MBS8576804-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-5 mAb

MBS8576804-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-5 mAb

MBS8576804-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-5 mAb

MBS8576804-01mLAF635 0.1mL(AF635)
EUR 565

Human anti-Human IL-8 mAb

MBS8576808-005mg 0.05mg
EUR 325

Human anti-Human IL-8 mAb

MBS8576808-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-8 mAb

MBS8576808-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-8 mAb

MBS8576808-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-8 mAb

MBS8576808-01mLAF635 0.1mL(AF635)
EUR 565

human anti-human IL-1β mAb

E409C11-h100 100μL
EUR 395
Description: Available in various conjugation types.

human anti-human IL-10 mAb

E409C17-h100 100μL
EUR 395
Description: Available in various conjugation types.

Human anti-Human IL-10 mAb

MBS8576810-005mg 0.05mg
EUR 325

Human anti-Human IL-10 mAb

MBS8576810-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-10 mAb

MBS8576810-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-10 mAb

MBS8576810-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-10 mAb

MBS8576810-01mLAF635 0.1mL(AF635)
EUR 565

Human anti-Human IL-1beta mAb

MBS8576798-005mg 0.05mg
EUR 325

Human anti-Human IL-1beta mAb

MBS8576798-01mLAF405L 0.1mL(AF405L)
EUR 565

Human anti-Human IL-1beta mAb

MBS8576798-01mLAF405S 0.1mL(AF405S)
EUR 565

Human anti-Human IL-1beta mAb

MBS8576798-01mLAF610 0.1mL(AF610)
EUR 565

Human anti-Human IL-1beta mAb

MBS8576798-01mLAF635 0.1mL(AF635)
EUR 565

rec IL-4 (human)

H-9630.0002 2.0µg
EUR 313.2

rec IL-4 (human)

H-9630.0010 10.0µg
EUR 1140

human anti-human IL-12/IL-23 p40 mAb(3H2)

E4A09D33-3H2 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

human anti-human IL-12/IL-23 p40 mAb(5N9)

E4A09D33-5N9 50ug
EUR 275
Description: Biotin-Conjugated, FITC-Conjugated , AF350 Conjugated , AF405M-Conjugated ,AF488-Conjugated, AF514-Conjugated ,AF532-Conjugated, AF555-Conjugated ,AF568-Conjugated , HRP-Conjugated, AF405S-Conjugated, AF405L-Conjugated , AF546-Conjugated, AF594-Conjugated , AF610-Conjugated, AF635-Conjugated , AF647-Conjugated , AF680-Conjugated , AF700-Conjugated , AF750-Conjugated , AF790-Conjugated , APC-Conjugated , PE-Conjugated , Cy3-Conjugated , Cy5-Conjugated , Cy5.5-Conjugated , Cy7-Conjugated Antibody

PE Anti-Human IL-4 Antibody

DL22181F-20Tests 20Tests
EUR 222.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody

DL22181F-50Tests 50Tests
EUR 320
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody

RD22181F-100Tests 100Tests
EUR 285
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody

RD22181F-100Testsx2 100Testsx2
EUR 427.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

PE Anti-Human IL-4 Antibody

RD22181F-20Tests 20Tests
EUR 112.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody

DL22182F-20Tests 20Tests
EUR 245
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

APC Anti-Human IL-4 Antibody

DL22182F-50Tests 50Tests
EUR 357.5
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of naïve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Rat Anti-Human IL-4, Antibody

GWB-600465 0.5 mg Ask for price

Rat Anti-Human IL-4, Antibody

GWB-ACBDBA 0.5 mg Ask for price

Rat Anti-Human IL-4, Antibody

GWB-C54D97 0.5 mg Ask for price

APC Anti-Human IL-4 Antibody

RD22182F-100Tests 100Tests
EUR 330
Description: IL-4 is a pleiotropic cytokine that is produced by activated T cells, mast cells, and basophils. IL-4 elicits many different biological responses but has two dominant functions. The first is regulating differentiation of na?ve CD4+ T cell to the Th2 type. Th2 cells produce IL-4, IL-5, IL-10, and IL-13, which tend to favor a humoral immune response while suppressing a cell-mediated immune response controlled by Th1 cells. The second is regulating IgE and IgG1 production by B cells.

Preclinical Antitumor Exercise and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Affected person-Derived Xenografts

Guanylyl cyclase C (GCC) is a novel therapeutic goal with expression restricted to the apical facet of epithelial cell tight junctions regarded as solely accessible by intravenously administered brokers on malignant tissues the place GCC expression is aberrant.
  • Within the current examine, we sought to judge the therapeutic potential of a second-generation investigational ADC, TAK-164, comprised of a human anti-GCC monoclonal antibody conjugated through a peptide linker to the extremely cytotoxic DNA alkylator, DGN549. The in vitro binding, payload launch, and in vitro exercise of TAK-164 was characterised motivating in vivo analysis.
  • The efficacy of TAK-164 and the connection to publicity, pharmacodynamic marker activation, and biodistribution was evaluated in xenograft fashions and first human tumor xenograft (PHTX) fashions. We show TAK-164 selectively binds to, is internalized by, and has potent cytotoxic results towards GCC-expressing cells in vitro.
  • A single intravenous administration of TAK-164 (0.76 mg/kg) resulted in vital progress charge inhibition in PHTX fashions of mCRC. Moreover, imaging research characterised TAK-164 uptake and exercise and confirmed constructive relationships between GCC expression and tumor uptake which correlated with antitumor exercise.
  • Collectively, our information counsel that TAK-164 is very energetic in a number of GCC constructive tumors together with these refractory to TAK-264, a GCC-targeted auristatin ADC. A powerful relationship between uptake of 89Zr-labeled TAK-164, ranges of GCC expression and, most notably, response to TAK-164 remedy in GCC expressing xenografts and PHTX fashions.
  • These information supported the scientific growth of TAK-164 as a part of a first-in-human scientific trial (NCT03449030).

BRAK, Recombinant, Human

MBS650956-5x002mg 5x0.02mg
EUR 2055

Human BRAK ELISA Kit

EHB0616 96Tests
EUR 625.2

Human BRAK GENLISA ELISA

KBH0061 1 x 96 wells
EUR 286

Recombinant Human BRAK (CXCL14)

7-01783 5µg Ask for price

Recombinant Human BRAK (CXCL14)

7-01784 20µg Ask for price

Recombinant Human BRAK (CXCL14)

7-01785 1mg Ask for price

Recombinant Human BRAK (CXCL14)

MBS145415-0005mg 0.005mg
EUR 240

Recombinant Human BRAK (CXCL14)

MBS145415-002mg 0.02mg
EUR 310

Recombinant Human BRAK (CXCL14)

MBS145415-1mg 1mg
EUR 2880

Recombinant Human BRAK (CXCL14)

MBS145415-5x1mg 5x1mg
EUR 12630

Recombinant Human BRAK protein

CD02230-10ug 10ug
EUR 275
Description: Recombinant Human C-X-C Motif Chemokine 14 is produced by our E.coli expression system and the target gene encoding Ser35-Glu111 is expressed.

Recombinant Human BRAK protein

CD02230-50ug 50ug
EUR 823
Description: Recombinant Human C-X-C Motif Chemokine 14 is produced by our E.coli expression system and the target gene encoding Ser35-Glu111 is expressed.

CXCL14/BRAK, human recombinant

4278-10 each
EUR 288

CXCL14/BRAK, human recombinant

4278-1000 each
EUR 3348

CXCL14/BRAK, human recombinant

4278-50 each
EUR 705.6

Recombinant Human CXCL14 (BRAK)

Z102375 20 µg
EUR 195
Description: Chemokine (CXC motif) ligand 14, also known as breast and kidney-expressed chemokine (BRAK), is a CXC chemokine that is a potent chemoattractant for neutrophils but not for T-cells, B-cells, monocytes or granulocytes. Mature CXCL14 has many conserved features of the CXC family and is 30% homologous to the MIP-α and MIP-β sequences, but differs in that it has an additional five amino acid sequence in between the third and fourth cysteines and a short N-terminus. It is usually highly expressed near its fibroblast source and in epidermal fibroblasts and keratinocytes of skin, but is absent from cancer cells.

Recombinant Human CXCL14 (BRAK)

Z102379 1.0 mg
EUR 3900
Description: Chemokine (CXC motif) ligand 14, also known as breast and kidney-expressed chemokine (BRAK), is a CXC chemokine that is a potent chemoattractant for neutrophils but not for T-cells, B-cells, monocytes or granulocytes. Mature CXCL14 has many conserved features of the CXC family and is 30% homologous to the MIP-α and MIP-β sequences, but differs in that it has an additional five amino acid sequence in between the third and fourth cysteines and a short N-terminus. It is usually highly expressed near its fibroblast source and in epidermal fibroblasts and keratinocytes of skin, but is absent from cancer cells.

BRAK (CXCL14) Human Recombinant

rAP-0116 Inquiry Ask for price

Recombinant Human CXCL14 (BRAK)

MBS4159847-002mg 0.02mg
EUR 345

Recombinant Human CXCL14 (BRAK)

MBS4159847-1mg 1(mg)
EUR 4600

Recombinant Human CXCL14 (BRAK)

MBS4159847-5x1mg 5x1mg
EUR 20445

Anti-Human BRAK Rabbit Polyclonal Antibody

TA328274 100 µg Ask for price

Mouse Monoclonal anti-human CXCL14 (BRAK)

hAP-0213 100ug
EUR 250

Sheep Polyclonal anti-Human CXCL14 (BRAK)

hAP-5820 50ug
EUR 400

Human CXCL14/BRAK ELISA Kit

E16HE0215 96T
EUR 833.33

Human BRAK (CXCL14) Recombinant Protein

100-139 20 µg
EUR 196.35
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Human BRAK (CXCL14) Recombinant Protein

100-139S 5 µg
EUR 92.4
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Recombinant Human BRAK (CXCL14) Protein

PROTO95715-2 20ug
EUR 380.4
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 α and β. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Human BRAK Recombinant Protein Lyophilized

IHUBRAKRLY5UG each
EUR 341
Description: Human BRAK Recombinant Protein Lyophilized

Human BRAK Recombinant Protein Lyophilized

MBS8431375-INQUIRE INQUIRE Ask for price

Recombinant Human CXCL14/BRAK Protein

E40KMP1499 20ug
EUR 495

BRAK (CXCL14) Human Recombinant Protein

PROTO95715 Regular: 20ug
EUR 380.4
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.;The CXCL14 is purified by proprietary chromatographic techniques.

Recombinant Human CXCL14/BRAK Protein

RP00348 10 μg
EUR 1137.5

BRAK

chm-001 5µg
EUR 60
Description: Recombinant Human BRAK (CXCL14)

BRAK antibody

70R-BR016 50 ug
EUR 312
Description: Affinity purified Rabbit polyclonal BRAK antibody

BRAK antibody

MBS535940-005mg 0.05mg
EUR 465

BRAK antibody

MBS535940-5x005mg 5x0.05mg
EUR 1945

Recombinant Human BRAK (CXCL14), His Tag

7-01780 5µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag

7-01781 20µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag

7-01782 1mg Ask for price

Recombinant Human BRAK (CXCL14), His Tag

MBS143271-0001mg 0.001mg
EUR 240

Recombinant Human BRAK (CXCL14), His Tag

MBS143271-0005mg 0.005mg
EUR 310

Recombinant Human BRAK (CXCL14), His Tag

MBS143271-005mg 0.05mg
EUR 1360

Recombinant Human BRAK (CXCL14), His Tag

MBS143271-5x005mg 5x0.05mg
EUR 5800

Biotinylated Anti-Human BRAK Rabbit Polyclonal Antibody

TA328273 50 µg Ask for price

BRAK Human Recombinant (CXCL14), His-Tag

rAP-0119 Inquiry Ask for price

Human BRAK Flow Cytometry Assay - Group 6

HX87213 96 Tests
EUR 270

Nori® Human CXCL14/BRAK ELISA Kit

GR106314 96-well
EUR 461

Human, BRAK Human Recombinant Protein (CXCL14), His-Tag

PROTO95715-1 Regular: 5ug
EUR 380.4
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.66 kDa. ;The Human BRAK contains a 10 a.a. fusion His tag at N-Terminus. ;The BRAK is purified by proprietary chromatographic techniques.

Recombinant Human BRAK Protein, His, E.coli-1ug

QP11201-1ug 1ug
EUR 186

Recombinant Human BRAK Protein, His, E.coli-5ug

QP11201-5ug 5ug
EUR 241.2

Recombinant Human BRAK Protein, His, E.coli-50ug

QP11201-50ug 50ug
EUR 1513.2

BRAK (AP)

MBS6465940-01mL 0.1mL
EUR 635

BRAK (AP)

MBS6465940-5x01mL 5x0.1mL
EUR 2700

BRAK (PE)

MBS6465950-01mL 0.1mL
EUR 635

BRAK (PE)

MBS6465950-5x01mL 5x0.1mL
EUR 2700

BRAK His

chm-239 1µg
EUR 60
Description: Recombinant Human BRAK (CXCL14), His Tag

BRAK (APC)

MBS6465941-01mL 0.1mL
EUR 635

BRAK (APC)

MBS6465941-5x01mL 5x0.1mL
EUR 2700

BRAK (HRP)

MBS6465944-01mL 0.1mL
EUR 635

BRAK (HRP)

MBS6465944-5x01mL 5x0.1mL
EUR 2700

BRAK (FITC)

MBS6465943-01mL 0.1mL
EUR 635

BRAK (FITC)

MBS6465943-5x01mL 5x0.1mL
EUR 2700

Recombinant Human BRAK Protein, Untagged, E.coli-1mg

QP10538-1mg 1mg
EUR 3308.4

Recombinant Human BRAK Protein, Untagged, E.coli-5ug

QP10538-5ug 5ug
EUR 186

Recombinant Human CXCL14/BRAK protein, No Tag

MBS1560747-005mg 0.05mg
EUR 320

Recombinant Human CXCL14/BRAK protein, No Tag

MBS1560747-01mg 0.1mg
EUR 410

Recombinant Human CXCL14/BRAK protein, No Tag

MBS1560747-5x01mg 5x0.1mg
EUR 1520

Recombinant Human BRAK Protein, Untagged, E.coli-20ug

QP10538-20ug 20ug
EUR 241.2

BRAK (Biotin)

MBS6465942-01mL 0.1mL
EUR 635

BRAK (Biotin)

MBS6465942-5x01mL 5x0.1mL
EUR 2700

BRAK (Biotin)

MBS618734-0025mg 0.025mg
EUR 420

BRAK (Biotin)

MBS618734-005mg 0.05mg
EUR 525

BRAK (Biotin)

MBS618734-5x005mg 5x0.05mg
EUR 2210

CXCL14 (BRAK)

MBS517297-002mg 0.02mg
EUR 290

CXCL14 (BRAK)

MBS517297-1mg 1mg
EUR 3715

CXCL14 (BRAK)

MBS517297-5x1mg 5x1mg
EUR 16450

BRAK protein

30R-AB037 20 ug
EUR 312
Description: Human recombinant BRAK protein

BRAK protein

MBS539458-002mg 0.02mg
EUR 465

BRAK protein

MBS539458-5x002mg 5x0.02mg
EUR 1945

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human)

4-PAB607Hu01
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  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK)

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