Binding mechanisms of therapeutic antibodies to human CD20

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controlpeptidecomprimary-antibodies

Binding mechanisms of therapeutic antibodies to human CD20

 

Monoclonal antibodies (mAbs) focusing on human antigen CD20 (cluster of differentiation 20) represent vital immunotherapies for the therapy of B cell malignancies and autoimmune ailments. Sort I and II therapeutic mAbs differ in B cell binding properties and cytotoxic results, reflecting differential interplay mechanisms with CD20. Right here we current 3.7- to 4.7-angstrom cryo-electron microscopy constructions of full-length CD20 in complexes with prototypical sort I rituximab and ofatumumab and kind II obinutuzumab.
The constructions and binding thermodynamics show that upon binding to CD20, sort II mAbs type terminal complexes that preclude recruitment of further mAbs and complement parts, whereas sort I complexes act as molecular seeds to extend mAb native focus for environment friendly complement activation. Amongst sort I mAbs, ofatumumab complexes show optimum geometry for complement recruitment. The uncovered mechanisms ought to assist rational design of next-generation immunotherapies focusing on CD20.

Rational Design of a Sturdy Antibody-Like Small Molecule Inhibitor Nanoplatform for Enhanced Photoimmunotherapy

Immune checkpoint blockade of programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway through antibody is a potent technique for T cells transforming. Nonetheless, the efficiency of antibody is partly compromised by its excessive worth, instability, threat of autoimmune illness, and many others. Small molecule inhibitors are attention-grabbing alternate options to antibodies.
Nonetheless, tumor-specific supply of small molecule inhibitor to the goal web site for reinforcing the interruption of PD-L1/PD-1 pathway isn’t reported. Herein, we designed a tumor-specific supply nanoplatform that would effectively ship the small molecule inhibitor to the exact goal web site, significantly enhancing the blocking impact of PD-L1/PD-1 pathway. Hyaluronic acid (HA) was conjugated with chlorin e6 (Ce6), leading to a HA-Ce6 conjugate (HC).
The nanoplatform was constructed by the HC micelles with encapsulation of small molecule inhibitor BMS 202 (BMS) to type BMS/HC micelles. The goal property of HA, mixed with the hyaluronidase-induced degradation of HA in tumor web site, permits the as-prepared micelles with tumor-specific supply of BMS for blocking PD-L1/PD-1 pathway.
Cooperative therapy with the photosensitizer Ce6, the current therapeutic nanoplatform demonstrated glorious photoimmunotherapy for tumor regression in distant tumors and lung metastasis. This technique of tumor-specific supply of small molecule inhibitors gives an efficient pathway to strengthen the blocking efficacy of PD-L1/PD-1 on efficient photoimmunotherapy.
controlpeptidecomprimary-antibodies

controlpeptidecomprimary-antibodies

Anti-human IL-4 antibody
STJ15100046 250 µg
EUR 367
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

Anti-IL-4 antibody
STJ96510 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody
STJ93699 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody
STJ93700 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4.

anti- IL-4 antibody
FNab04278 100µg
EUR 585
Description: Antibody raised against IL-4

anti- IL-4 antibody
FNab04279 100µg
EUR 585
Description: Antibody raised against IL-4

anti- IL-4 antibody
FNab09861 100µg
EUR 548.75
Description: Antibody raised against IL-4

anti- IL-4 antibody
LSMab09861 100 ug
EUR 386

Anti-IL-4 antibody
PAab04278 100 ug
EUR 412

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349

Recombinant Human IL-2 Protein
PROTP60568-4 50ug
EUR 317
Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Recombinant Human IL-17F Protein
PROTQ96PD4-4 25ug
EUR 317
Description: IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Recombinant human IL-17F is a disulfide-linked homodimer of 30.1 kDa, consisting of two 133 amino acid residue chains.

Recombinant Human IL-6 Protein
PROTP05231-4 20ug
EUR 317
Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

Recombinant Human IL-3 Protein
PROTP08700-4 10ug
EUR 317
Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.

mAb mouse anti-human IL-4
CT253 0.5 mg
EUR 260

Anti-mouse IL-4 antibody
STJ15100035 250 µg
EUR 336
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-mouse IL-4 antibody
STJ15100036 500 µg
EUR 527
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity.

Anti-mouse IL-4 antibody
STJ15100037 250 µg
EUR 367
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-IL-4 alpha antibody
STJ97665 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4Ralpha.

Anti-IL-4 alpha antibody
STJ93702 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4Ralpha.

Anti-IL-4 alpha antibody
STJ93703 200 µl
EUR 197
Description: Rabbit polyclonal to IL-4Ralpha.

Recombinant Human IL-12 p80 Protein
PROTP29460-4 10ug
EUR 317
Description: IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

Recombinant Human IL-13 Variant Protein
PROTP35225-4 10ug
EUR 317
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. PeproTech's genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112.

Human Interleukin-4 (IL-4)
1-CSB-EP011659HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli

IL-4, Interleukin-4, human
RC212-15 5ug
EUR 104.38

Recombinant Human IL-16 (129 a.a.) Protein
PROTQ14005-4 10ug
EUR 317
Description: IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.5 kDa protein consisting of 130 amino acid residues.

pAb rabbit anti-human IL-4 receptor
CT248 0.5 mg
EUR 184

IL-4
E21-050 10ug
EUR 343

IL-4
E21-D03 10ug
EUR 343

IL-4
E21-K15 10ug
EUR 343

IL-4
E13-015-1 10μg
EUR 161

IL-4
E13-015-2 50μg
EUR 505

IL-4
MO15071 500 ug
EUR 910

Recombinant Human IL-8 (72 a.a.) (CXCL8) Protein
PROTP10145-4 25ug
EUR 317
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

mAb mouse anti-rat IL-4
CT028 0.5 mg
EUR 260

mAb mouse anti-rat IL-4
CT029 0.5 mg
EUR 260

pAb rabbit anti-rat IL-4
CT058 0.5 mg
EUR 184

mAb mouse anti-monkey IL-4
CT103 0.5 mg
EUR 260

mAb rat anti-mouse IL-4
CT324 0.5 mg
EUR 260

mAb rat anti-mouse IL-4
CT337 0.5 mg
EUR 260

Swine IL-10 Recombinant Protein
R00021-4 5ug/vial
EUR 259
Description: IL-10 is an anti-inflammatory cytokine and a member of the IL-10 family of cytokines, which have indispensable functions in many infectious and inflammatory diseases. Swine IL-10 Recombinant Protein is purified interleukin-10 produced in yeast.

Mouse IL-13 Recombinant Protein
R00077-4 5ug/vial
EUR 259
Description: IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. Mouse IL-13 Recombinant Protein is purified interleukin-13 produced in yeast.

Feline IL-6 Recombinant Protein
R00102-4 5ug/vial
EUR 259
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Feline IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.

Feline IL-2 Recombinant Protein
R00387-4 5ug/vial
EUR 259
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Feline IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.

Mouse IL-17A Recombinant Protein
R00421-4 5ug/vial
EUR 259
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Mouse IL-17A Recombinant Protein is purified interleukin-17A produced in yeast.

Dolphin IL-8 Recombinant Protein
R00423-4 5ug/vial
EUR 259
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Dolphin IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.

Swine IL-21 Recombinant Protein
R00459-4 5ug/vial
EUR 259
Description: The cytokine interleukin-21 (IL-21) regulates the proliferation and differentiation of T and B lymphocytes, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. Swine IL-21 Recombinant Protein is purified interleukin-21 produced in yeast.

Equine IL-1ra Recombinant Protein
R00651-4 5ug/vial
EUR 259
Description: Interleukin-1 Receptor Antagonist Protein (IL-1F3, IL-1ra) belongs to the IL-1 family of cytokines, whose members play key roles in the development and regulation of inflammation. IL-1 receptor antagonist (IL-1ra; IL-1F3) reduces inflammation by blocking the binding of the agonist receptor ligands. Equine IL-1 Receptor Antagonist Recombinant Protein is purified interleukin-1 receptor antagonist protein (IL-1F3, IL-1ra) produced in yeast.

Human IL-4 Protein
abx060798-20ug 20 ug
EUR 467

Recombinant Human IL-4
P0052 100ug
EUR 522.36
Description: Recombinant Human protein for IL-4

rec IL-4 (human)
H-9630.0002 2.0µg
EUR 261

rec IL-4 (human)
H-9630.0010 10.0µg
EUR 950

Recombinant Human IL-4
SJB02-03 10µg/vial
EUR 285

Recombinant Human IL-4
SJB02-05 100µg/vial
EUR 720

Recombinant Human IL-4
SJB02-06 30µg/vial
EUR 430

IL-4, human recombinant
4137-10
EUR 278

IL-4, human recombinant
4137-1000
EUR 3704

IL-4, human recombinant
4137-50
EUR 697

Interleukin-4/IL-4
E21-K74 10ug
EUR 343

Human Interleukin-4 (IL-4) Antibody
32184-05111 150 ug
EUR 261

IL-7 Interleukin-7 Human Recombinant Protein, His Tag
PROTP13232-4 Regular: 10ug
EUR 317
Description: IL-7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.97 kDa with an amino-terminal hexahistidine tag. ;The IL-7 His-Tag protein is purified by proprietary chromatographic techniques.

Recombinant Human 4-1BB Receptor Protein
PROTQ07011-4 20ug
EUR 317
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Recombinant Human PF-4 (CXCL4) Protein
PROTP02776-4 20ug
EUR 317
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Human FibrOut 4, for brain, neural
4-21552 1 ml Ask for price

Human FibrOut 4, for brain, neural
4-21553 5 x 1 ml Ask for price

Feline IL-1 beta Recombinant Protein
R00101-4 5ug/vial
EUR 259
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Feline IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Feline IL-1 alpha Recombinant Protein
R01144-4 5ug/vial
EUR 259
Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Feline IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast.

Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280

IL-4 antigen
E6IE600107 20ug
EUR 343

IL-4 antigen
E6L00107 20ug
EUR 382

rHu IL-4
AK8329-0005 5µg Ask for price

rHu IL-4
AK8329-0020 20µg Ask for price

rHu IL-4
AK8329-0100 100µg Ask for price

rHu IL-4
AK8329-1000 1mg Ask for price

IL-4 antibody
PAab09861 100 ug
EUR 386

IL-4 Antibody
5137-200
EUR 370

IL-4 Antibody
5137-30T
EUR 146

Anti-Phospho-IL-4 alpha (Y497) antibody
STJ90720 200 µl
EUR 197
Description: Rabbit polyclonal to Phospho-IL-4Ralpha (Y497).

Anti-IL-4 Antibody [11B11], Unconjugated-100ug
QAB81-100ug 100ug
EUR 149

Anti-IL-4 Antibody [11B11], Unconjugated-500ug
QAB81-500ug 500ug
EUR 233

Anti-IL-4 Antibody [11B11], APC-100ug
QAB81-APC-100ug 100ug
EUR 276

Anti-IL-4 Antibody [11B11], APC-25ug
QAB81-APC-25ug 25ug
EUR 131

Anti-IL-4 Antibody [11B11], PE-100ug
QAB81-PE-100ug 100ug
EUR 259

Anti-IL-4 Antibody [11B11], PE-25ug
QAB81-PE-25ug 25ug
EUR 141

IL-4, Interleukin-4, monkey
RC222-15 5ug
EUR 104.38

IL-4, Interleukin-4, rat
RC252-15 5ug
EUR 104.38

Interleukin 4 (IL-4) Antibody
abx234279-100ug 100 ug
EUR 551

Human Interleukin 4, IL-4 ELISA KIT
CSB-E04633h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 4, IL-4 ELISA KIT
1-CSB-E04633h
  • EUR 500.00
  • EUR 3402.00
  • EUR 1820.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 4(IL-4)ELISA Kit
GA-E0132HM-48T 48T
EUR 289

Human Interleukin 4(IL-4)ELISA Kit
GA-E0132HM-96T 96T
EUR 466

IL-4 Interleukin-4 Human Recombinant Protein
PROTP05112-1 Regular: 20ug
EUR 317
Description: Interleukin-4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 130 amino acids and having a molecular mass of 15kDa. ;The IL-4 is purified by proprietary chromatographic techniques.

Human Interleukin 4,IL-4 ELISA KIT
201-12-0093 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Preclinical Antitumor Exercise and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Affected person-Derived Xenografts

Guanylyl cyclase C (GCC) is a novel therapeutic goal with expression restricted to the apical facet of epithelial cell tight junctions regarded as solely accessible by intravenously administered brokers on malignant tissues the place GCC expression is aberrant.
  • Within the current examine, we sought to judge the therapeutic potential of a second-generation investigational ADC, TAK-164, comprised of a human anti-GCC monoclonal antibody conjugated through a peptide linker to the extremely cytotoxic DNA alkylator, DGN549. The in vitro binding, payload launch, and in vitro exercise of TAK-164 was characterised motivating in vivo analysis.
  • The efficacy of TAK-164 and the connection to publicity, pharmacodynamic marker activation, and biodistribution was evaluated in xenograft fashions and first human tumor xenograft (PHTX) fashions. We show TAK-164 selectively binds to, is internalized by, and has potent cytotoxic results towards GCC-expressing cells in vitro.
  • A single intravenous administration of TAK-164 (0.76 mg/kg) resulted in vital progress charge inhibition in PHTX fashions of mCRC. Moreover, imaging research characterised TAK-164 uptake and exercise and confirmed constructive relationships between GCC expression and tumor uptake which correlated with antitumor exercise.
  • Collectively, our information counsel that TAK-164 is very energetic in a number of GCC constructive tumors together with these refractory to TAK-264, a GCC-targeted auristatin ADC. A powerful relationship between uptake of 89Zr-labeled TAK-164, ranges of GCC expression and, most notably, response to TAK-164 remedy in GCC expressing xenografts and PHTX fashions.
  • These information supported the scientific growth of TAK-164 as a part of a first-in-human scientific trial (NCT03449030).

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RD-BRAK-Mu-48Tests 48 Tests
EUR 511

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RD-BRAK-Mu-96Tests 96 Tests
EUR 709

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RD-BRAK-Ra-48Tests 48 Tests
EUR 534

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RD-BRAK-Ra-96Tests 96 Tests
EUR 742

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
DLR-BRAK-Mu-48T 48T
EUR 508
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
DLR-BRAK-Mu-96T 96T
EUR 661
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
DLR-BRAK-Ra-48T 48T
EUR 528
Description: A sandwich quantitative ELISA assay kit for detection of Rat Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
DLR-BRAK-Ra-96T 96T
EUR 690
Description: A sandwich quantitative ELISA assay kit for detection of Rat Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RDR-BRAK-Mu-48Tests 48 Tests
EUR 534

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RDR-BRAK-Mu-96Tests 96 Tests
EUR 742

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RDR-BRAK-Ra-48Tests 48 Tests
EUR 558

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RDR-BRAK-Ra-96Tests 96 Tests
EUR 776

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349

BRAK antibody
70R-BR016 50 ug
EUR 273
Description: Affinity purified Rabbit polyclonal BRAK antibody

BRAK protein
30R-AB037 20 ug
EUR 273
Description: Human recombinant BRAK protein

Human BRAK ELISA Kit
EHB0616 96Tests
EUR 521

Recombinant Human BRAK (CXCL14)
7-01783 5µg Ask for price

Recombinant Human BRAK (CXCL14)
7-01784 20µg Ask for price

Recombinant Human BRAK (CXCL14)
7-01785 1mg Ask for price

CXCL14/BRAK, human recombinant
4278-10
EUR 240

CXCL14/BRAK, human recombinant
4278-1000
EUR 2790

CXCL14/BRAK, human recombinant
4278-50
EUR 588

Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280

BRAK Recombinant Protein
40-401-0005mg 0.005 mg
EUR 259.25
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

BRAK Recombinant Protein
40-401-002mg 0.02 mg
EUR 364.25
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Recombinant Human CXCL14/BRAK Protein
RP00348 10 μg
EUR 193

BRAK (CXCL14) Human Recombinant Protein
PROTO95715 Regular: 20ug
EUR 317
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.;The CXCL14 is purified by proprietary chromatographic techniques.

Recombinant Human BRAK (CXCL14) Protein
PROTO95715-2 20ug
EUR 317
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 α and β. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Sheep BRAK ELISA Kit
ESB0616 96Tests
EUR 521

BRAK, CXCL14, murine (mouse)
RC332-25 5ug
EUR 104.38

Mouse BRAK ELISA Kit
EMB0616 96Tests
EUR 521

Anserine BRAK ELISA Kit
EAB0616 96Tests
EUR 521

Rabbit BRAK ELISA Kit
ERTB0616 96Tests
EUR 521

Monkey BRAK ELISA Kit
EMKB0616 96Tests
EUR 521

Porcine BRAK ELISA Kit
EPB0616 96Tests
EUR 521

Rat BRAK ELISA Kit
ERB0616 96Tests
EUR 521

Canine BRAK ELISA Kit
ECB0616 96Tests
EUR 521

Chicken BRAK ELISA Kit
ECKB0616 96Tests
EUR 521

Goat BRAK ELISA Kit
EGTB0616 96Tests
EUR 521

Bovine BRAK ELISA Kit
EBB0616 96Tests
EUR 521

Recombinant Human BRAK (CXCL14), His Tag
7-01780 5µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag
7-01781 20µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag
7-01782 1mg Ask for price

BRAK (CXCL14) Rat Recombinant Protein
PROTQ8K453 Regular: 20ug
EUR 317
Description: CXCL14 Rat Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.;The CXCL14 is purified by proprietary chromatographic techniques.

BRAK (CXCL14) Mouse Recombinant Protein
PROTQ9WUQ5 Regular: 20ug
EUR 317
Description: CXCL14 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.;The CXCL14 is purified by proprietary chromatographic techniques.

Guinea Pig BRAK ELISA Kit
EGB0616 96Tests
EUR 521

BRAK ELISA Kit (Rat) (OKDD00770)
OKDD00770 96 Wells
EUR 1001
Description: Description of target: ;Species reactivity: Rat;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: <0.058ng/mL

BRAK ELISA Kit (Rat) (OKCD04290)
OKCD04290 96 Wells
EUR 857
Description: Description of target: ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.2 pg/mL

Nori® Human CXCL14/BRAK ELISA Kit
GR106314 96-well
EUR 461

Recombinant Human BRAK Protein, Untagged, E.coli-1mg
QP10538-1mg 1mg
EUR 2757

Recombinant Human BRAK Protein, Untagged, E.coli-20ug
QP10538-20ug 20ug
EUR 201

Recombinant Human BRAK Protein, Untagged, E.coli-5ug
QP10538-5ug 5ug
EUR 155

Recombinant Human BRAK Protein, His, E.coli-1ug
QP11201-1ug 1ug
EUR 155

Recombinant Human BRAK Protein, His, E.coli-50ug
QP11201-50ug 50ug
EUR 1261

Recombinant Human BRAK Protein, His, E.coli-5ug
QP11201-5ug 5ug
EUR 201

Human, BRAK Human Recombinant Protein (CXCL14), His-Tag
PROTO95715-1 Regular: 5ug
EUR 317
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.66 kDa. ;The Human BRAK contains a 10 a.a. fusion His tag at N-Terminus. ;The BRAK is purified by proprietary chromatographic techniques.

Human Breast And Kidney Expressed Chemokine (BRAK) Protein
20-abx168163
  • EUR 676.00
  • EUR 272.00
  • EUR 2068.00
  • EUR 801.00
  • EUR 481.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Nori Equine CXCL14/BRAK ELISA Kit
GR106914 96-well
EUR 461

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit
SCB607Hu-10x96wellstestplate 10x96-wells test plate
EUR 5647.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit
SCB607Hu-1x48wellstestplate 1x48-wells test plate
EUR 552.76
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit
SCB607Hu-1x96wellstestplate 1x96-wells test plate
EUR 746.8
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit
SCB607Hu-5x96wellstestplate 5x96-wells test plate
EUR 3060.6
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) CLIA Kit
4-SCB607Hu
  • EUR 5698.00
  • EUR 3061.00
  • EUR 747.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Double-antibody Sandwich chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK)Serum, plasma and other biological fluids

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
SEB607Hu-10x96wellstestplate 10x96-wells test plate
EUR 4502.43
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
SEB607Hu-1x48wellstestplate 1x48-wells test plate
EUR 458.44
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
SEB607Hu-1x96wellstestplate 1x96-wells test plate
EUR 612.05
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
SEB607Hu-5x96wellstestplate 5x96-wells test plate
EUR 2454.23
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
4-SEB607Hu
  • EUR 4553.00
  • EUR 2405.00
  • EUR 613.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Breast and kidney expressed chemokine, BRAK ELISA Kit
CSB-E10025h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human Breast and kidney expressed chemokine, BRAK in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Breast and kidney expressed chemokine, BRAK ELISA Kit
1-CSB-E10025h
  • EUR 900.00
  • EUR 5476.00
  • EUR 2900.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Breast and kidney expressed chemokine, BRAK in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human)
4-PAB607Hu01
  • EUR 239.00
  • EUR 2391.00
  • EUR 598.00
  • EUR 299.00
  • EUR 211.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK)

Human Breast and kidney expressed chemokine(BRAK)ELISA Kit
GA-E0101HM-48T 48T
EUR 289

Human Breast and kidney expressed chemokine(BRAK)ELISA Kit
GA-E0101HM-96T 96T
EUR 466

Human Breast and kidney expressed chemokine,BRAK ELISA Kit
201-12-0062 96 tests
EUR 440
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) CLIA Kit
20-abx190238
  • EUR 7911.00
  • EUR 4215.00
  • EUR 973.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Breast And Kidney Expressed Chemokine (BRAK) Protein (Active)
20-abx655570
  • EUR 1080.00
  • EUR 398.00
  • EUR 3585.00
  • EUR 1302.00
  • EUR 732.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
20-abx150834
  • EUR 7112.00
  • EUR 3792.00
  • EUR 879.00
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Breast and kidney expressed chemokine(BRAK)ELISA Kit
QY-E00767 96T
EUR 361

Human Breast and kidney expressed chemokine,BRAK ELISA Kit
CN-03482H1 96T
EUR 458

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