Binding mechanisms of therapeutic antibodies to human CD20

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controlpeptidecomprimary-antibodies

Binding mechanisms of therapeutic antibodies to human CD20

 

Monoclonal antibodies (mAbs) focusing on human antigen CD20 (cluster of differentiation 20) represent vital immunotherapies for the therapy of B cell malignancies and autoimmune ailments. Sort I and II therapeutic mAbs differ in B cell binding properties and cytotoxic results, reflecting differential interplay mechanisms with CD20. Right here we current 3.7- to 4.7-angstrom cryo-electron microscopy constructions of full-length CD20 in complexes with prototypical sort I rituximab and ofatumumab and kind II obinutuzumab.
The constructions and binding thermodynamics show that upon binding to CD20, sort II mAbs type terminal complexes that preclude recruitment of further mAbs and complement parts, whereas sort I complexes act as molecular seeds to extend mAb native focus for environment friendly complement activation. Amongst sort I mAbs, ofatumumab complexes show optimum geometry for complement recruitment. The uncovered mechanisms ought to assist rational design of next-generation immunotherapies focusing on CD20.

Rational Design of a Sturdy Antibody-Like Small Molecule Inhibitor Nanoplatform for Enhanced Photoimmunotherapy

Immune checkpoint blockade of programmed cell death-ligand 1/programmed cell death-1 (PD-L1/PD-1) pathway through antibody is a potent technique for T cells transforming. Nonetheless, the efficiency of antibody is partly compromised by its excessive worth, instability, threat of autoimmune illness, and many others. Small molecule inhibitors are attention-grabbing alternate options to antibodies.
Nonetheless, tumor-specific supply of small molecule inhibitor to the goal web site for reinforcing the interruption of PD-L1/PD-1 pathway isn’t reported. Herein, we designed a tumor-specific supply nanoplatform that would effectively ship the small molecule inhibitor to the exact goal web site, significantly enhancing the blocking impact of PD-L1/PD-1 pathway. Hyaluronic acid (HA) was conjugated with chlorin e6 (Ce6), leading to a HA-Ce6 conjugate (HC).
The nanoplatform was constructed by the HC micelles with encapsulation of small molecule inhibitor BMS 202 (BMS) to type BMS/HC micelles. The goal property of HA, mixed with the hyaluronidase-induced degradation of HA in tumor web site, permits the as-prepared micelles with tumor-specific supply of BMS for blocking PD-L1/PD-1 pathway.
Cooperative therapy with the photosensitizer Ce6, the current therapeutic nanoplatform demonstrated glorious photoimmunotherapy for tumor regression in distant tumors and lung metastasis. This technique of tumor-specific supply of small molecule inhibitors gives an efficient pathway to strengthen the blocking efficacy of PD-L1/PD-1 on efficient photoimmunotherapy.
controlpeptidecomprimary-antibodies

controlpeptidecomprimary-antibodies

Anti-human IL-4 antibody
STJ15100046 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of human IL-4 in immunoassays such as ELISA and ELISpot.

anti- IL-4 antibody
FNab04278 100µg
EUR 702
Description: Antibody raised against IL-4

anti- IL-4 antibody
FNab04279 100µg
EUR 702
Description: Antibody raised against IL-4

anti- IL-4 antibody
LSMab09861 100 ug
EUR 463.2

anti- IL-4 antibody
FNab09861 100µg
EUR 658.5
Description: Antibody raised against IL-4

Anti-IL-4 antibody
PAab04278 100 ug
EUR 494.4

Anti-IL-4 antibody
STJ96510 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody
STJ93699 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Anti-IL-4 antibody
STJ93700 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4.

Recombinant Human IL-17F Protein
PROTQ96PD4-4 25ug
EUR 380.4
Description: IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate proliferation and activation of T-cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. Recombinant human IL-17F is a disulfide-linked homodimer of 30.1 kDa, consisting of two 133 amino acid residue chains.

Recombinant Human IL-6 Protein
PROTP05231-4 20ug
EUR 380.4
Description: IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant human IL-6 is a 20.9 kDa protein containing 184 amino acid residues.

Recombinant Human IL-3 Protein
PROTP08700-4 10ug
EUR 380.4
Description: IL-3 is a hematopoietic growth factor that promotes the survival, differentiation and proliferation of committed progenitor cells of the megakaryocyte, granulocyte-macrophage, erythroid, eosinophil, basophil and mast cell lineages. Produced by T cells, mast cells and eosinophils, IL-3 enhances thrombopoieses, phagocytosis, and antibody-mediated cellular cytotoxicity. Its ability to activate monocytes suggests that IL-3 may have additional immunoregulatory roles. Many of the IL-3 activities depend upon co-stimulation with other cytokines. IL-3 is species-specific, variably glycosylated cytokine. Recombinant human IL-3 is a 15.0 kDa globular protein containing 133 amino acid residues.

Recombinant Human IL-2 Protein
PROTP60568-4 50ug
EUR 380.4
Description: IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 418.8

mAb mouse anti-human IL-4
CT253 0.5 mg
EUR 312

Recombinant Human IL-12 p80 Protein
PROTP29460-4 10ug
EUR 380.4
Description: IL-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23, or can form a homodimer designated as IL-12 p80. Elevated levels of IL-12 p80 are correlated with macrophage recruitment and increased inflammation in asthma and respiratory viral infection models. Recombinant human IL-12 p80 is an 80.0 kDa disulfide linked homodimer consisting of two p40 chains of IL-12.

Recombinant Human IL-13 Variant Protein
PROTP35225-4 10ug
EUR 380.4
Description: IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells. Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites. IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8. IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching resulting in increased production of IgE. Blocking of IL-13 activity inhibits the pathophysiology of asthma. Human and murine IL-13 is cross-species reactive. A variant of IL-13 shows enhanced functional activity compared with the wild type IL-13. PeproTech's genetic variant, termed human IL-13 analog, is a mature 114 amino acid protein with a substitution of Q for R at position 112.

Human Interleukin-4 (IL-4)
1-CSB-EP011659HU
  • EUR 456.00
  • EUR 256.80
  • EUR 1570.80
  • EUR 672.00
  • EUR 1047.60
  • EUR 314.40
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Interleukin-4(IL-4) expressed in E.coli

IL-4, Interleukin-4, human
RC212-15 5ug
EUR 125.26

Anti-mouse IL-4 antibody
STJ15100035 250 µg
EUR 403.2
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-mouse IL-4 antibody
STJ15100036 500 µg
EUR 632.4
Description: This monoclonal antibody is recommended for neutralization of mouse IL-4 bioactivity.

Anti-mouse IL-4 antibody
STJ15100037 250 µg
EUR 440.4
Description: This monoclonal antibody enables sensitive and specific detection of mouse IL-4 in immunoassays such as ELISA and ELISpot.

Anti-IL-4 alpha antibody
STJ97665 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Anti-IL-4 alpha antibody
STJ93702 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Anti-IL-4 alpha antibody
STJ93703 200 µl
EUR 236.4
Description: Rabbit polyclonal to IL-4Ralpha.

Recombinant Human IL-16 (129 a.a.) Protein
PROTQ14005-4 10ug
EUR 380.4
Description: IL-16 is a CD8+ T cell-derived cytokine that induces chemotaxis of CD4+ T cells and CD4+ monocytes and eosinophils. Analysis by gel filtration suggests that, under physiological conditions, hIL-16 exists predominantly as a noncovalently linked multimer, but that some IL-16 may exist as a monomer. However, only the multimeric form appears to possess chemotactic activity, suggesting that receptor cross-linking may be required for activity. IL-16 also induces expression of IL-2 receptor (IL-2R) and MHC class II molecules on CD4 + T cells. Human and murine IL-16 show significant cross-species reactivity. Recombinant human IL-16 is a 13.5 kDa protein consisting of 130 amino acid residues.

IL-4
E13-015-1 10μg
EUR 193.2

IL-4
E13-015-2 50μg
EUR 606

IL-4
MO15071 500 ug
EUR 1092

IL-4
E21-050 10ug
EUR 411.6

IL-4
E21-D03 10ug
EUR 411.6

IL-4
E21-K15 10ug
EUR 411.6

pAb rabbit anti-human IL-4 receptor
CT248 0.5 mg
EUR 220.8

Recombinant Human IL-8 (72 a.a.) (CXCL8) Protein
PROTP10145-4 25ug
EUR 380.4
Description: IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

IL-4, human recombinant
4137-10
EUR 333.6

IL-4, human recombinant
4137-1000
EUR 4444.8

IL-4, human recombinant
4137-50
EUR 836.4

Human IL-4 Protein
abx060798-20ug 20 ug
EUR 560.4

Recombinant Human IL-4
P0052 100ug
EUR 626.83
Description: Recombinant Human protein for IL-4

rec IL-4 (human)
H-9630.0002 2.0µg
EUR 313.2

rec IL-4 (human)
H-9630.0010 10.0µg
EUR 1140

Recombinant Human IL-4
SJB02-03 10µg/vial
EUR 342

Recombinant Human IL-4
SJB02-05 100µg/vial
EUR 864

Recombinant Human IL-4
SJB02-06 30µg/vial
EUR 516

Interleukin-4/IL-4
E21-K74 10ug
EUR 411.6

Swine IL-10 Recombinant Protein
R00021-4 5ug/vial
EUR 310.8
Description: IL-10 is an anti-inflammatory cytokine and a member of the IL-10 family of cytokines, which have indispensable functions in many infectious and inflammatory diseases. Swine IL-10 Recombinant Protein is purified interleukin-10 produced in yeast.

Mouse IL-13 Recombinant Protein
R00077-4 5ug/vial
EUR 310.8
Description: IL-13 is an important mediator of allergic inflammation and disease. In addition to effects on immune cells, IL-13 is implicated as a central mediator of the physiologic changes induced by allergic inflammation in many tissues. Mouse IL-13 Recombinant Protein is purified interleukin-13 produced in yeast.

Feline IL-6 Recombinant Protein
R00102-4 5ug/vial
EUR 310.8
Description: Interleukin-6 (IL-6) is an interleukin that acts as both a pro-inflammatory and anti-inflammatory cytokine. Feline IL-6 Recombinant Protein is purified interleukin-6 produced in yeast.

Feline IL-2 Recombinant Protein
R00387-4 5ug/vial
EUR 310.8
Description: Interleukin-2 (IL-2) is a cytokine produced by T-helper cells in response to antigenic or mitogenic stimulation. It is required for T-cell proliferation and other activities crucial to the regulation of the immune response. Feline IL-2 Recombinant Protein is purified interleukin-2 produced in yeast.

Mouse IL-17A Recombinant Protein
R00421-4 5ug/vial
EUR 310.8
Description: IL-17A is a member of the IL-17 family of cytokines, whose members are involved in numerous immune regulatory functions. IL-17 induces the production of many other cytokines, chemokines, and prostaglandins. Mouse IL-17A Recombinant Protein is purified interleukin-17A produced in yeast.

Dolphin IL-8 Recombinant Protein
R00423-4 5ug/vial
EUR 310.8
Description: Interleukin-8 (IL-8), also known as CXCL8, is an ELR-positive CXC family member chemokine produced by macrophages and other cell types such as epithelial cells. ELR-positive CXC chemokines such as IL-8 specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. Dolphin IL-8 Recombinant Protein is purified interleukin-8 produced in yeast.

Swine IL-21 Recombinant Protein
R00459-4 5ug/vial
EUR 310.8
Description: The cytokine interleukin-21 (IL-21) regulates the proliferation and differentiation of T and B lymphocytes, modulates the cytotoxic activity and survival of NK and CD8+ T cells, and suppresses the maturation of dendritic cells. Swine IL-21 Recombinant Protein is purified interleukin-21 produced in yeast.

Equine IL-1ra Recombinant Protein
R00651-4 5ug/vial
EUR 310.8
Description: Interleukin-1 Receptor Antagonist Protein (IL-1F3, IL-1ra) belongs to the IL-1 family of cytokines, whose members play key roles in the development and regulation of inflammation. IL-1 receptor antagonist (IL-1ra; IL-1F3) reduces inflammation by blocking the binding of the agonist receptor ligands. Equine IL-1 Receptor Antagonist Recombinant Protein is purified interleukin-1 receptor antagonist protein (IL-1F3, IL-1ra) produced in yeast.

Human Interleukin-4 (IL-4) Antibody
32184-05111 150 ug
EUR 313.2

IL-7 Interleukin-7 Human Recombinant Protein, His Tag
PROTP13232-4 Regular: 10ug
EUR 380.4
Description: IL-7 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 152 amino acids fragment (26-177) and having a total molecular mass of 21.97 kDa with an amino-terminal hexahistidine tag. ;The IL-7 His-Tag protein is purified by proprietary chromatographic techniques.

mAb mouse anti-rat IL-4
CT028 0.5 mg
EUR 312

mAb mouse anti-rat IL-4
CT029 0.5 mg
EUR 312

pAb rabbit anti-rat IL-4
CT058 0.5 mg
EUR 220.8

mAb mouse anti-monkey IL-4
CT103 0.5 mg
EUR 312

mAb rat anti-mouse IL-4
CT324 0.5 mg
EUR 312

mAb rat anti-mouse IL-4
CT337 0.5 mg
EUR 312

Human FibrOut 4, for brain, neural
4-21552 1 ml Ask for price

Human FibrOut 4, for brain, neural
4-21553 5 x 1 ml Ask for price

Recombinant Human 4-1BB Receptor Protein
PROTQ07011-4 20ug
EUR 380.4
Description: 4-1BB Receptor, a member of the TNF superfamily of receptors, is mainly expressed on the surface of a variety of T cells, but also found in B cells, monocytes, and various transformed cell lines. 4-1BB Receptor binds to 4-1BBL to provide a co-stimulatory signal for T lymphocytes. Signaling by 4-1BB Receptor has been implicated in the antigen-presentation process and generation of cytotoxic T cells. The human 4-1BB Receptor gene codes for a 255 amino acid type I transmembrane protein containing a 17 amino acid N-terminal signal sequence, a 169 amino acid extracellular domain, a 27 amino acid transmembrane domain and a 42 amino acid cytoplasmic domain. Recombinant human soluble 4-1BB Receptor is a 167 amino acid polypeptide (17.7 kDa), which contains the cysteine rich TNFR-like extracellular domain of 4-1BB Receptor.

Recombinant Human PF-4 (CXCL4) Protein
PROTP02776-4 20ug
EUR 380.4
Description: PF-4 is a CXC chemokine that is expressed in megakaryocytes and stored in the α-granules of platelets. PF-4 is chemotactic towards neutrophils and monocytes and has been shown to inhibit angiogenesis. Recombinant human PF-4 is a 7.8 kDa protein containing 70 amino acid residues, including the four highly conserved residues present in CXC chemokines.

Feline IL-1 beta Recombinant Protein
R00101-4 5ug/vial
EUR 310.8
Description: IL-1 beta (IL-1β) is a member of the interleukin 1 family of cytokines. The IL-1 beta cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. Feline IL-1 beta Recombinant Protein is purified interleukin-1 beta cytokine produced in yeast.

Feline IL-1 alpha Recombinant Protein
R01144-4 5ug/vial
EUR 310.8
Description: IL-1 alpha (IL-1α, IL-1F1) is a member of the interleukin 1 family of cytokines. IL-1 alpha is an inflammatory cytokine active in the initiation of the inflammatory reaction and in driving Th1 and Th17 inflammatory responses. Feline IL-1 alpha Recombinant Protein is purified interleukin-1 alpha cytokine produced in yeast.

rHu IL-4
AK8329-0005 5µg Ask for price

rHu IL-4
AK8329-0020 20µg Ask for price

rHu IL-4
AK8329-0100 100µg Ask for price

rHu IL-4
AK8329-1000 1mg Ask for price

IL-4 Antibody
5137-200
EUR 444

IL-4 Antibody
5137-30T
EUR 175.2

IL-4 antigen
E6IE600107 20ug
EUR 411.6

IL-4 antigen
E6L00107 20ug
EUR 458.4

IL-4 antibody
PAab09861 100 ug
EUR 463.2

IL-4 Antibody
R30605 100 ug
EUR 419

IL-4 Antibody
R30841 100 ug
EUR 419

IL-4 Antibody
RQ4162 100 ug
EUR 419

IL-4 Antibody
RQ5106 100ul
EUR 419

IL-4 Antibody
V7884-100UG 100 ug
EUR 499
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

IL-4 Antibody
V7884-20UG 20 ug
EUR 219
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

IL-4 Antibody
V7884SAF-100UG 100 ug
EUR 499
Description: Interleukin-4 (IL-4), also designated B cell stimulatory factor-1, is a glycosylated cytokine secreted by activated T lymphocytes, basophils and mast cells. The secreted IL-4 protein promotes the growth and differentiation of cells that participate in immune defense by favoring such events as the expansion of the Th2 lineage relative to Th1 cells. These T helper cell subsets are defined by their pattern of cytokine secretion: Th1 cells secrete IL-2, TNF, while Th2 cells secrete IL-4, IL-5 and IL-10. Another key immunological function of IL-4 is to induce immunoglobulin class switching. IL-4 has been shown to induce the production of IgE and enhance IgG4 secretion by B cells, but suppress the production of IgM, IgA, IgG1, IgG2 and IgG3. It has been determined that Stat6 is rapidly tyrosine phosphorylated following stimulation of IL-3 or IL-4, but is not detectably phosphorylated following stimulation with IL-2, IL-12 or erythropoietin.

IL-4 Antibody
V8351-100UG 100 ug
EUR 499
Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12.

IL-4 Antibody
V8351-20UG 20 ug
EUR 219
Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12.

IL-4 Antibody
V8351SAF-100UG 100 ug
EUR 499
Description: IL-4 is a pleiotropic cytokine produced by activated T cells, mast cells, and basophils. IL-4 is a potent lymphoid cell growth factor, which stimulates the growth and activation of certain B cells and T cells. IL-4 is important for regulation of T helper subset development. IL-4 is expressed primarily by activated Th2 cells and NK cells, and at lower levels by mast cells, and basophils. IL-4 signals through the IL-4R, and dendritic cell IL-12.

IL-4 Antibody
F49086-0.08ML 0.08 ml
EUR 165

IL-4 Antibody
F49086-0.4ML 0.4 ml
EUR 379

Human Interleukin 4, IL-4 ELISA KIT
CSB-E04633h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Interleukin 4, IL-4 ELISA KIT
1-CSB-E04633h
  • EUR 600.00
  • EUR 4082.40
  • EUR 2184.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Interleukin 4, IL-4 in samples from serum, tissue homogenates, cell culture supernates, saliva. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Interleukin 4,IL-4 ELISA KIT
CN-03206H1 96T
EUR 520.8

Human Interleukin 4,IL-4 ELISA KIT
CN-03206H2 48T
EUR 340.8

Recombinant Human Interleukin-4 (rHu IL-4)
AK9839-0010 10ug
EUR 780

Recombinant Human Interleukin-4 (rHu IL-4)
AK9839-0030 30ug
EUR 1356

Recombinant Human Interleukin-4 (rHu IL-4)
AK9839-0100 100ug
EUR 2040

Preclinical Antitumor Exercise and Biodistribution of a Novel Anti-GCC Antibody-Drug Conjugate in Affected person-Derived Xenografts

Guanylyl cyclase C (GCC) is a novel therapeutic goal with expression restricted to the apical facet of epithelial cell tight junctions regarded as solely accessible by intravenously administered brokers on malignant tissues the place GCC expression is aberrant.
  • Within the current examine, we sought to judge the therapeutic potential of a second-generation investigational ADC, TAK-164, comprised of a human anti-GCC monoclonal antibody conjugated through a peptide linker to the extremely cytotoxic DNA alkylator, DGN549. The in vitro binding, payload launch, and in vitro exercise of TAK-164 was characterised motivating in vivo analysis.
  • The efficacy of TAK-164 and the connection to publicity, pharmacodynamic marker activation, and biodistribution was evaluated in xenograft fashions and first human tumor xenograft (PHTX) fashions. We show TAK-164 selectively binds to, is internalized by, and has potent cytotoxic results towards GCC-expressing cells in vitro.
  • A single intravenous administration of TAK-164 (0.76 mg/kg) resulted in vital progress charge inhibition in PHTX fashions of mCRC. Moreover, imaging research characterised TAK-164 uptake and exercise and confirmed constructive relationships between GCC expression and tumor uptake which correlated with antitumor exercise.
  • Collectively, our information counsel that TAK-164 is very energetic in a number of GCC constructive tumors together with these refractory to TAK-264, a GCC-targeted auristatin ADC. A powerful relationship between uptake of 89Zr-labeled TAK-164, ranges of GCC expression and, most notably, response to TAK-164 remedy in GCC expressing xenografts and PHTX fashions.
  • These information supported the scientific growth of TAK-164 as a part of a first-in-human scientific trial (NCT03449030).

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
DLR-BRAK-Mu-48T 48T
EUR 609.6
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
DLR-BRAK-Mu-96T 96T
EUR 793.2
Description: A sandwich quantitative ELISA assay kit for detection of Mouse Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates or other biological fluids.

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
DLR-BRAK-Ra-48T 48T
EUR 633.6
Description: A sandwich quantitative ELISA assay kit for detection of Rat Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
DLR-BRAK-Ra-96T 96T
EUR 828
Description: A sandwich quantitative ELISA assay kit for detection of Rat Breast And Kidney Expressed Chemokine (BRAK) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RDR-BRAK-Mu-48Tests 48 Tests
EUR 640.8

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RDR-BRAK-Mu-96Tests 96 Tests
EUR 890.4

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RDR-BRAK-Ra-48Tests 48 Tests
EUR 669.6

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RDR-BRAK-Ra-96Tests 96 Tests
EUR 931.2

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RD-BRAK-Mu-48Tests 48 Tests
EUR 613.2

Mouse Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RD-BRAK-Mu-96Tests 96 Tests
EUR 850.8

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RD-BRAK-Ra-48Tests 48 Tests
EUR 640.8

Rat Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
RD-BRAK-Ra-96Tests 96 Tests
EUR 890.4

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 418.8

BRAK antibody
70R-BR016 50 ug
EUR 327.6
Description: Affinity purified Rabbit polyclonal BRAK antibody

BRAK protein
30R-AB037 20 ug
EUR 327.6
Description: Human recombinant BRAK protein

Human BRAK ELISA Kit
EHB0616 96Tests
EUR 625.2

CXCL14/BRAK, human recombinant
4278-10
EUR 288

CXCL14/BRAK, human recombinant
4278-1000
EUR 3348

CXCL14/BRAK, human recombinant
4278-50
EUR 705.6

Recombinant Human BRAK (CXCL14)
7-01783 5µg Ask for price

Recombinant Human BRAK (CXCL14)
7-01784 20µg Ask for price

Recombinant Human BRAK (CXCL14)
7-01785 1mg Ask for price

Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 336

Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 336

Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 336

BRAK Recombinant Protein
40-401-0005mg 0.005 mg
EUR 311.1
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

BRAK Recombinant Protein
40-401-002mg 0.02 mg
EUR 437.1
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 alpha and beta. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

BRAK (CXCL14) Human Recombinant Protein
PROTO95715 Regular: 20ug
EUR 380.4
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.;The CXCL14 is purified by proprietary chromatographic techniques.

Recombinant Human BRAK (CXCL14) Protein
PROTO95715-2 20ug
EUR 380.4
Description: Breast and Kidney-expressed chemokine (BRAK) is a CXC chemokine expressed in normal tissue in the absence of inflammatory stimuli, and infrequently expressed in cancer cell lines. BRAK is known to be a highly selective monocyte chemoattractant. However, main function and receptor selectivity is unknown at this time. BRAK contains the four highly conserved cysteine residues present in CXC chemokines. The sequence of the mature protein consists of 87 amino acid residues, and is approximately 30% homologous to the sequences of MIP-2 α and β. Recombinant human BRAK is a 9.4 kDa protein containing 77 amino acid residues.

Recombinant Human CXCL14/BRAK Protein
RP00348 10 μg
EUR 231.6

Mouse BRAK ELISA Kit
EMB0616 96Tests
EUR 625.2

Sheep BRAK ELISA Kit
ESB0616 96Tests
EUR 625.2

Rat BRAK ELISA Kit
ERB0616 96Tests
EUR 625.2

Monkey BRAK ELISA Kit
EMKB0616 96Tests
EUR 625.2

Porcine BRAK ELISA Kit
EPB0616 96Tests
EUR 625.2

Rabbit BRAK ELISA Kit
ERTB0616 96Tests
EUR 625.2

Goat BRAK ELISA Kit
EGTB0616 96Tests
EUR 625.2

Bovine BRAK ELISA Kit
EBB0616 96Tests
EUR 625.2

Canine BRAK ELISA Kit
ECB0616 96Tests
EUR 625.2

Chicken BRAK ELISA Kit
ECKB0616 96Tests
EUR 625.2

Anserine BRAK ELISA Kit
EAB0616 96Tests
EUR 625.2

BRAK, CXCL14, murine (mouse)
RC332-25 5ug
EUR 125.26

Recombinant Human BRAK (CXCL14), His Tag
7-01780 5µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag
7-01781 20µg Ask for price

Recombinant Human BRAK (CXCL14), His Tag
7-01782 1mg Ask for price

Nori® Human CXCL14/BRAK ELISA Kit
GR106314 96-well
EUR 553.2

Recombinant Human BRAK Protein, Untagged, E.coli-1mg
QP10538-1mg 1mg
EUR 3308.4

Recombinant Human BRAK Protein, Untagged, E.coli-20ug
QP10538-20ug 20ug
EUR 241.2

Recombinant Human BRAK Protein, Untagged, E.coli-5ug
QP10538-5ug 5ug
EUR 186

Recombinant Human BRAK Protein, His, E.coli-1ug
QP11201-1ug 1ug
EUR 186

Recombinant Human BRAK Protein, His, E.coli-50ug
QP11201-50ug 50ug
EUR 1513.2

Recombinant Human BRAK Protein, His, E.coli-5ug
QP11201-5ug 5ug
EUR 241.2

BRAK ELISA Kit (Rat) (OKCD04290)
OKCD04290 96 Wells
EUR 1028.4
Description: Description of target: ;Species reactivity: Rat;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 6.2 pg/mL

BRAK ELISA Kit (Rat) (OKDD00770)
OKDD00770 96 Wells
EUR 1201.2
Description: Description of target: ;Species reactivity: Rat;Application: ;Assay info: Quantitative Sandwich ELISA;Sensitivity: <0.058ng/mL

Guinea Pig BRAK ELISA Kit
EGB0616 96Tests
EUR 625.2

BRAK (CXCL14) Rat Recombinant Protein
PROTQ8K453 Regular: 20ug
EUR 380.4
Description: CXCL14 Rat Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.;The CXCL14 is purified by proprietary chromatographic techniques.

BRAK (CXCL14) Mouse Recombinant Protein
PROTQ9WUQ5 Regular: 20ug
EUR 380.4
Description: CXCL14 Mouse Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 77 amino acids and having a molecular mass of 9.4kDa.;The CXCL14 is purified by proprietary chromatographic techniques.

Human, BRAK Human Recombinant Protein (CXCL14), His-Tag
PROTO95715-1 Regular: 5ug
EUR 380.4
Description: CXCL14 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10.66 kDa. ;The Human BRAK contains a 10 a.a. fusion His tag at N-Terminus. ;The BRAK is purified by proprietary chromatographic techniques.

Human Breast And Kidney Expressed Chemokine (BRAK) Protein
20-abx168163
  • EUR 811.20
  • EUR 326.40
  • EUR 2481.60
  • EUR 961.20
  • EUR 577.20
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Nori Equine CXCL14/BRAK ELISA Kit
GR106914 96-well
EUR 553.2

Human Breast and kidney expressed chemokine, BRAK ELISA Kit
CSB-E10025h-24T 1 plate of 24 wells
EUR 198
Description: Quantitativesandwich ELISA kit for measuring Human Breast and kidney expressed chemokine, BRAK in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human Breast and kidney expressed chemokine, BRAK ELISA Kit
1-CSB-E10025h
  • EUR 1080.00
  • EUR 6571.20
  • EUR 3480.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human Breast and kidney expressed chemokine, BRAK in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human Breast and kidney expressed chemokine,BRAK ELISA Kit
CN-03482H1 96T
EUR 549.6

Human Breast and kidney expressed chemokine,BRAK ELISA Kit
CN-03482H2 48T
EUR 368.4

Human Breast and kidney expressed chemokine(BRAK)ELISA Kit
GA-E0101HM-48T 48T
EUR 346.8

Human Breast and kidney expressed chemokine(BRAK)ELISA Kit
GA-E0101HM-96T 96T
EUR 559.2

Human Breast and kidney expressed chemokine,BRAK ELISA Kit
201-12-0062 96 tests
EUR 528
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
20-abx150834
  • EUR 8534.40
  • EUR 4550.40
  • EUR 1054.80
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Breast And Kidney Expressed Chemokine (BRAK) CLIA Kit
20-abx190238
  • EUR 9493.20
  • EUR 5058.00
  • EUR 1167.60
  • 10 × 96 tests
  • 5 × 96 tests
  • 96 tests

Human Breast And Kidney Expressed Chemokine (BRAK) Protein (Active)
20-abx655570
  • EUR 1296.00
  • EUR 477.60
  • EUR 4302.00
  • EUR 1562.40
  • EUR 878.40
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Breast And Kidney Expressed Chemokine (BRAK) Polyclonal Antibody (Human)
4-PAB607Hu01
  • EUR 286.80
  • EUR 2869.20
  • EUR 717.60
  • EUR 358.80
  • EUR 253.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Breast And Kidney Expressed Chemokine (BRAK)

Human Breast and kidney expressed chemokine(BRAK)ELISA Kit
QY-E00767 96T
EUR 433.2

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
SEB607Hu-10x96wellstestplate 10x96-wells test plate
EUR 5402.92
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
SEB607Hu-1x48wellstestplate 1x48-wells test plate
EUR 550.13
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
SEB607Hu-1x96wellstestplate 1x96-wells test plate
EUR 734.46
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
SEB607Hu-5x96wellstestplate 5x96-wells test plate
EUR 2945.08
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK) ELISA Kit
4-SEB607Hu
  • EUR 5463.60
  • EUR 2886.00
  • EUR 735.60
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. with no significant corss-reactivity with analogues from other species.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit
SCB607Hu-10x96wellstestplate 10x96-wells test plate
EUR 6777.36
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit
SCB607Hu-1x48wellstestplate 1x48-wells test plate
EUR 663.31
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit
SCB607Hu-1x96wellstestplate 1x96-wells test plate
EUR 896.16
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

Human Breast And Kidney Expressed Chemokine (BRAK)CLIA Kit
SCB607Hu-5x96wellstestplate 5x96-wells test plate
EUR 3672.72
Description: This is Double-antibody Sandwich Chemiluminescent immunoassay for detection of Human Breast And Kidney Expressed Chemokine (BRAK) in serum, plasma and other biological fluids.

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